Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer

A Karlstaedt, J Moslehi, RA de Boer - Nature Reviews Cardiology, 2022 - nature.com
Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in
the world. The emerging field of cardio-oncology has revealed that these seemingly …

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on …

J van der Velden, FW Asselbergs… - Cardiovascular …, 2022 - academic.oup.com
Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity

D Lu, S Chatterjee, K Xiao, I Riedel… - European heart …, 2022 - academic.oup.com
Aims Cardiotoxicity leading to heart failure (HF) is a growing problem in many cancer
survivors. As specific treatment strategies are not available, RNA discovery pipelines were …

Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages

Y Chen, Y Liu, Y Wang, X Chen, C Wang… - Journal of Experimental …, 2022 - Springer
Background Immune checkpoint inhibitor-related cardiotoxicity is one of the most lethal
adverse effects, and thus, the identification of underlying mechanisms for developing …

Physical exercise: a novel tool to protect mitochondrial health

D Sorriento, E Di Vaia, G Iaccarino - Frontiers in physiology, 2021 - frontiersin.org
Mitochondrial dysfunction is a crucial contributor to heart diseases. Alterations in energetic
metabolism affect crucial homeostatic processes, such asATP production, the generation of …

The innate immune system in cardiovascular diseases and its role in doxorubicin-induced cardiotoxicity

A Bhagat, P Shrestha, ES Kleinerman - International journal of molecular …, 2022 - mdpi.com
Innate immune cells are the early responders to infection and tissue damage. They play a
critical role in the initiation and resolution of inflammation in response to insult as well as …

Cardiovascular toxicity of immune checkpoint inhibitors: clinical risk factors

F Pirozzi, R Poto, L Aran, A Cuomo, MR Galdiero… - Current Oncology …, 2021 - Springer
Abstract Purpose of Review Immune checkpoint inhibitors, such as monoclonal antibodies
targeting CTLA-4, PD-1, and PD-L1, have improved the outcome of many malignancies, but …

Breast cancer chemotherapy induces vascular dysfunction and hypertension through a NOX4-dependent mechanism

P Szczepaniak, M Siedlinski… - The Journal of …, 2022 - Am Soc Clin Investig
Cardiovascular disease is the major cause of morbidity and mortality in breast cancer
survivors. Chemotherapy contributes to this risk. We aimed to define the mechanisms of long …

Advanced cancer is also a heart failure syndrome: a hypothesis

MS Anker, AP Sanz, JL Zamorano… - European Journal of …, 2021 - Wiley Online Library
We present the hypothesis that advanced stage cancer is also a heart failure syndrome. It
can develop independently of or in addition to cardiotoxic effects of anti‐cancer therapies …

LncRNA-miRNA interaction is involved in colorectal cancer pathogenesis by modulating diverse signaling pathways

SH Alshahrani, ZSM Al-Hadeithi, SG Almalki… - … -Research and Practice, 2023 - Elsevier
LncRNAs function as molecular sponges for miRNAs to control their availability for targeting
mRNA molecules. This procedure indirectly regulates the expression of cancer-related …