Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer
Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in
the world. The emerging field of cardio-oncology has revealed that these seemingly …
the world. The emerging field of cardio-oncology has revealed that these seemingly …
Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on …
J van der Velden, FW Asselbergs… - Cardiovascular …, 2022 - academic.oup.com
Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …
research to improve diagnostics, and to discover and test novel preventive and curative …
A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity
D Lu, S Chatterjee, K Xiao, I Riedel… - European heart …, 2022 - academic.oup.com
Aims Cardiotoxicity leading to heart failure (HF) is a growing problem in many cancer
survivors. As specific treatment strategies are not available, RNA discovery pipelines were …
survivors. As specific treatment strategies are not available, RNA discovery pipelines were …
Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages
Y Chen, Y Liu, Y Wang, X Chen, C Wang… - Journal of Experimental …, 2022 - Springer
Background Immune checkpoint inhibitor-related cardiotoxicity is one of the most lethal
adverse effects, and thus, the identification of underlying mechanisms for developing …
adverse effects, and thus, the identification of underlying mechanisms for developing …
Physical exercise: a novel tool to protect mitochondrial health
D Sorriento, E Di Vaia, G Iaccarino - Frontiers in physiology, 2021 - frontiersin.org
Mitochondrial dysfunction is a crucial contributor to heart diseases. Alterations in energetic
metabolism affect crucial homeostatic processes, such asATP production, the generation of …
metabolism affect crucial homeostatic processes, such asATP production, the generation of …
The innate immune system in cardiovascular diseases and its role in doxorubicin-induced cardiotoxicity
A Bhagat, P Shrestha, ES Kleinerman - International journal of molecular …, 2022 - mdpi.com
Innate immune cells are the early responders to infection and tissue damage. They play a
critical role in the initiation and resolution of inflammation in response to insult as well as …
critical role in the initiation and resolution of inflammation in response to insult as well as …
Cardiovascular toxicity of immune checkpoint inhibitors: clinical risk factors
Abstract Purpose of Review Immune checkpoint inhibitors, such as monoclonal antibodies
targeting CTLA-4, PD-1, and PD-L1, have improved the outcome of many malignancies, but …
targeting CTLA-4, PD-1, and PD-L1, have improved the outcome of many malignancies, but …
Breast cancer chemotherapy induces vascular dysfunction and hypertension through a NOX4-dependent mechanism
P Szczepaniak, M Siedlinski… - The Journal of …, 2022 - Am Soc Clin Investig
Cardiovascular disease is the major cause of morbidity and mortality in breast cancer
survivors. Chemotherapy contributes to this risk. We aimed to define the mechanisms of long …
survivors. Chemotherapy contributes to this risk. We aimed to define the mechanisms of long …
Advanced cancer is also a heart failure syndrome: a hypothesis
MS Anker, AP Sanz, JL Zamorano… - European Journal of …, 2021 - Wiley Online Library
We present the hypothesis that advanced stage cancer is also a heart failure syndrome. It
can develop independently of or in addition to cardiotoxic effects of anti‐cancer therapies …
can develop independently of or in addition to cardiotoxic effects of anti‐cancer therapies …
LncRNA-miRNA interaction is involved in colorectal cancer pathogenesis by modulating diverse signaling pathways
LncRNAs function as molecular sponges for miRNAs to control their availability for targeting
mRNA molecules. This procedure indirectly regulates the expression of cancer-related …
mRNA molecules. This procedure indirectly regulates the expression of cancer-related …