Genetic regulation of central synapse formation and organization in Drosophila melanogaster

JC Duhart, TJ Mosca - Genetics, 2022 - academic.oup.com
A goal of modern neuroscience involves understanding how connections in the brain form
and function. Such a knowledge is essential to inform how defects in the exquisite …

[HTML][HTML] Internal state affects local neuron function in an early sensory processing center to shape olfactory behavior in Drosophila larvae

SR Odell, D Clark, N Zito, R Jain, H Gong… - Scientific Reports, 2022 - nature.com
Crawling insects, when starved, tend to have fewer head wavings and travel in straighter
tracks in search of food. We used the Drosophila melanogaster larva to investigate whether …

The Role of the Dopamine Transporter in the Effects of Amphetamine on Sleep and Sleep Architecture in Drosophila

CS Karam, BL Williams, SK Jones, JA Javitch - Neurochemical research, 2022 - Springer
The dopamine transporter (DAT) mediates the inactivation of released dopamine (DA)
through its reuptake, and thereby plays an important homeostatic role in dopaminergic …

[HTML][HTML] Transcriptional changes in specific subsets of Drosophila neurons following inhibition of the serotonin transporter

SL Bonanno, DE Krantz - Translational psychiatry, 2023 - nature.com
The transcriptional effects of SSRIs and other serotonergic drugs remain unclear, in part due
to the heterogeneity of postsynaptic cells, which may respond differently to changes in …

SynLight: a bicistronic strategy for simultaneous active zone and cell labeling in the Drosophila nervous system

MA Aimino, J Humenik, MJ Parisi… - G3: Genes …, 2023 - academic.oup.com
At synapses, chemical neurotransmission mediates the exchange of information between
neurons, leading to complex movement, behaviors, and stimulus processing. The immense …

[HTML][HTML] Navigating Like a Fly: Drosophila melanogaster as a Model to Explore the Contribution of Serotonergic Neurotransmission to Spatial Navigation

I Gajardo, S Guerra, JM Campusano - International Journal of Molecular …, 2023 - mdpi.com
Serotonin is a monoamine that acts in vertebrates and invertebrates as a modulator
promoting changes in the structure and activity of brain areas relevant to animal behavior …

Walking elicits global brain activity in Drosophila

S Aimon, KY Cheng, J Gjorgjieva, IC Grunwald Kadow - BioRxiv, 2022 - biorxiv.org
Movement and behavioral state influence perception, and a stimulus can elicit opposite
behavioral actions depending on whether the animal is moving toward or away from it. Here …

The unique synaptic circuitry of specialized olfactory glomeruli in Drosophila melanogaster

L Gruber, R Cantera, MW Pleijzier, M Steinert… - bioRxiv, 2022 - biorxiv.org
In the Drosophila olfactory system most odorants are encoded in the antennal lobe in a
combinatory way, activating several glomerular circuits. However, odorants of particular …

Functional Imaging of Learning-Induced Plasticity in the Central Nervous System with Genetically Encoded Reporters in Drosophila

T Boto, SM Tomchik - Cold Spring Harbor Protocols, 2024 - cshprotocols.cshlp.org
Learning and memory allow animals to adjust their behavior based on the predictive value
of their past experiences. Memories often exist in complex representations, spread across …

[HTML][HTML] Serotonin acts through multiple cellular targets during an olfactory critical period

A Mallick, HL Tan, JM Epstein, Q Gaudry, AM Dacks - bioRxiv, 2024 - ncbi.nlm.nih.gov
Abstract Serotonin (5-HT) is known to modulate early development during critical periods
when experience drives heightened levels of plasticity in neurons. Here, we take advantage …