Even when split into several chromosomes, DNA molecules that make up our genome are
too long to fit into the cell nuclei unless massively folded. Such folding must accommodate …

Previous studies have identified topologically associating domains (TADs) as basic units of
genome organization. We present evidence of a previously unreported level of genome …

The last two decades of work on chromosome conformation in eukaryotic nuclei have
revealed a complex and highly regulated hierarchy of architectural features, from self …

Although promoters and their enhancers are frequently contained within a topologically
associating domain (TAD), some developmentally important genes have their promoter and …

Polycomb group proteins have a critical role in silencing transcription during development. It
is commonly proposed that Polycomb-dependent changes in genome folding, which …

Chromosomes are exceedingly long topologically constrained polymers compacted in a cell
nucleus. We recently suggested that chromosomes are organized into loops by an active …

The kidney medulla is a specialized region with important homeostatic functions. It has been
implicated in genetic and developmental disorders along with ischemic and drug-induced …

Background The ring-shaped cohesin complex is an important factor for the formation of
chromatin loops and topologically associating domains (TADs) by loop extrusion. However …

High-resolution Micro-C maps identified a specialized class of regulatory DNAs termed
'tethering elements'(TEs) in Drosophila. These 300–500-bp elements facilitate specific long …

Enhancers are noncoding regulatory elements that instruct spatial and temporal specificity of
gene transcription in response to a variety of intrinsic and extrinsic signals during …