According to learning‐based models of behavior, food cue reactivity and craving are
conditioned responses that lead to increased eating and subsequent weight gain. However …

Although it is challenging for individuals with cocaine addiction to achieve abstinence, the
greatest difficulty is avoiding relapse to drug taking, which is often triggered by cues …

Summary Since 1997 the US National Institute on Drug Abuse has advocated a brain
disease model of addiction (BDMA). We assess the strength of evidence for the BDMA in …

Physical activity, and specifically exercise, has been suggested as a potential treatment for
drug addiction. In this review, we discuss clinical and preclinical evidence for the efficacy of …

Background The orexin (hypocretin) system is important for reward-driven motivation but has
not been implicated in the expression of a multiphenotype addicted state. Methods Rats …

The prefrontal cortex plays an important role in shaping cognition and behavior. Many
studies have shown that medial prefrontal cortex (mPFC) plays a key role in seeking …

Background Several theories propose alternative explanations for drug addiction. Objectives
We propose a general theory of transition to addiction that synthesizes knowledge …

Rationale Contemporary animal models of cocaine addiction focus on increasing the
amount of drug consumption to produce addiction-like behavior. However, another critical …

One decade ago, our laboratory provided the first direct evidence linking orexin/hypocretin
signaling with drug seeking by showing that activation of these neurons promotes …

How much, how often and how fast a drug reaches the brain determine the behavioural and
neuroplastic changes associated with the addiction process. Despite the critical nature of …