Auditory perception is our main gateway to communication with others via speech and
music, and it also plays an important role in alerting and orienting us to new events. This …

Organisms of all phyla express mechanosensitive ion channels with a wide range of
physiological functions. In recent years, several classes of mechanically gated ion channels …

Type I spiral ganglion neurons (SGNs) transmit sound information from cochlear hair cells to
the CNS. Using transcriptome analysis of thousands of single neurons, we demonstrate that …

Type I spiral ganglion neurons (SGNs) are the auditory afferents that transmit sound
information from cochlear inner hair cells (IHCs) to the brainstem. These afferents consist of …

Cochlear synaptopathy is the noise-induced or age-related loss of ribbon synapses between
inner hair cells (IHCs) and auditory-nerve fibers (ANFs), first reported in CBA/CaJ mice …

Cochlear implants (CI s) are considered the most successful neuroprosthesis as they enable
speech comprehension in the majority of half a million CI users suffering from sensorineural …

Subjective tinnitus is generally assumed to be a consequence of hearing loss. In animal
studies it has been demonstrated that acoustic trauma induced cochlear damage can lead to …

Recent studies on animal models have shown that noise exposure that does not lead to
permanent threshold shift (PTS) can cause considerable damage around the synapses …

The cochlea encodes sound pressures varying over six orders of magnitude by collective
operation of functionally diverse spiral ganglion neurons (SGNs). The mechanisms enabling …

Ribbon‐class synapses in the ear achieve analog to digital transformation of a continuously
graded membrane potential to all‐or‐none spikes. In mammals, several auditory nerve …