The function of the mammalian heart depends on the interplay between different cardiac cell
types. The deployment of these cells, with precise spatiotemporal regulation, is also …

The tongue is a complex multifunctional organ that interacts and senses both interoceptively
and exteroceptively. Although it is easily visible to almost all of us, it is relatively …

Muscle and bone interact via physical forces and secreted osteokines and myokines.
Physical forces are generated through gravity, locomotion, exercise, and external devices …

Many protein coding and non-coding genes interplay in governing skeletal muscle
formation. Nevertheless, comparing with the linear transcripts, functions of covalently closed …

A fundamental process during both embryo development and stem cell differentiation is the
control of cell lineage determination. In developing skeletal muscle, many of the diffusible …

Myogenic differentiation of human pluripotent stem cells (hPSCs) has been done by gene
overexpression or directed differentiation. However, viral integration, long-term culture, and …

Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma that histologically resembles
embryonic skeletal muscle. RMS occurs throughout the body and an exclusively myogenic …

MYOD is a master regulator of the skeletal myogenic program. But what regulates
expression of Myod? More than 20 years ago, studies established that Myod expression is …

Muscle precursor cells known as myoblasts are essential for muscle development and
regeneration. Notch signaling is an ancient intercellular communication mechanism that …

The communication between myogenic cells and their surrounding connective tissues is
indispensable for muscle morphogenesis. During late embryonic development in mice …