Modulation of the biochemical composition of the tumour microenvironment is a new frontier
of cancer therapy. Several immunosuppressive mechanisms operate in the milieu of most …

Neutrophil migration and its role during inflammation has been the focus of increased
interest in the past decade. Advances in live imaging and the use of new model systems …

Adenosine triphosphate (ATP) is a molecule that on one hand plays a central role in cellular
energetics and which on the other is a ubiquitous signaling molecule when released into the …

Extracellular nucleotides (eg, ATP, ADP, UTP, UDP) released by inflammatory cells interact
with specific purinergic P2 type receptors to modulate their recruitment and activation. The …

Extracellular nucleotides, mainly ATP, but also ADP, UTP, UDP and UDP-sugars,
adenosine, and adenine base participate in the “purinergic signalling” pathway, an …

Microglia are morphologically dynamic cells that rapidly extend their processes in response
to various stimuli including extracellular ATP. In this study, we tested the hypothesis that …

Intercellular calcium (Ca2+) waves (ICWs) represent the propagation of increases in
intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism …

Plasma membrane pannexin 1 channels (PANX1) release nucleotide find-me signals from
apoptotic cells to attract phagocytes. Here we show that the quinolone antibiotic …

Wound healing is an essential biological process that comprises sequential steps aimed at
restoring the architecture and function of damaged cells and tissues. This process begins …

Extracellular nucleotides have been recognized as important mediators of activation,
triggering multiple responses via plasma membrane receptors known as P2 receptors. P2 …