Mitochondrial oxidative stress, mitochondrial DNA damage and their role in age-related vascular dysfunction

Y Mikhed, A Daiber, S Steven - International journal of molecular sciences, 2015 - mdpi.com
The prevalence of cardiovascular diseases is significantly increased in the older population.
Risk factors and predictors of future cardiovascular events such as hypertension …

The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering …

M Oelze, S Kröller-Schön, P Welschof, T Jansen… - PloS one, 2014 - journals.plos.org
Objective In diabetes, vascular dysfunction is characterized by impaired endothelial function
due to increased oxidative stress. Empagliflozin, as a selective sodium-glucose co …

Oxidative stress in vascular disease and its pharmacological prevention

H Li, S Horke, U Förstermann - Trends in pharmacological sciences, 2013 - cell.com
Cardiovascular risk factors lead to enhanced production of reactive oxygen species (ROS)
generated by NADPH oxidase, xanthine oxidase (XO), the mitochondrial electron-transport …

eNOS uncoupling in cardiovascular diseases-the role of oxidative stress and inflammation

S Karbach, P Wenzel, A Waisman… - Current …, 2014 - ingentaconnect.com
Many cardiovascular diseases and drug-induced complications are associated with-or even
based on-an imbalance between the formation of reactive oxygen and nitrogen species …

[HTML][HTML] Health position paper and redox perspectives-Disease burden by transportation noise

M Sørensen, G Pershagen, JD Thacher, T Lanki… - Redox Biology, 2023 - Elsevier
Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization
concluded that chronic exposure to road traffic noise is a risk factor for ischemic heart …

Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway

H He, L Wang, Y Qiao, Q Zhou, H Li, S Chen… - Frontiers in …, 2020 - frontiersin.org
Background: Doxorubicin (Dox) can induce endotheliotoxicity and damage the vascular
endothelium (VE). The most principle mechanism might be excess reactive oxygen species …

Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression

A Karabatsiakis, C Böck, J Salinas-Manrique… - Translational …, 2014 - nature.com
Mitochondrial dysfunction might have a central role in the pathophysiology of depression.
Phenotypically, depression is characterized by lack of energy, concentration problems and …

[HTML][HTML] Redox-related biomarkers in human cardiovascular disease-classical footprints and beyond

A Daiber, O Hahad, I Andreadou, S Steven, S Daub… - Redox Biology, 2021 - Elsevier
Global epidemiological studies show that chronic non-communicable diseases such as
atherosclerosis and metabolic disorders represent the leading cause of premature mortality …

Resveratrol and the mitochondria: From triggering the intrinsic apoptotic pathway to inducing mitochondrial biogenesis, a mechanistic view

MR De Oliveira, SF Nabavi, A Manayi, M Daglia… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Background Mitochondria, the power plants of the cell, are known as a cross-road of
different cellular signaling pathways. These cytoplasmic double-membraned organelles play …

Molecular mechanisms of the crosstalk between mitochondria and NADPH oxidase through reactive oxygen species—studies in white blood cells and in animal …

S Kröller-Schön, S Steven, S Kossmann… - Antioxidants & redox …, 2014 - liebertpub.com
Aims: Oxidative stress is involved in the development of cardiovascular disease. There is a
growing body of evidence for a crosstalk between different enzymatic sources of oxidative …