The introduction of low-oxidation-state sulfur atoms is a popular strategy to provide
macromolecules with responsivity to oxidizing conditions, which in turn may confer them …

Vascular endothelial cells line the inner surface of the entire cardiovascular system as a
single layer and are involved in an impressive array of functions, ranging from the regulation …

Recently, we demonstrated that gene ablation of mitochondrial manganese superoxide
dismutase and aldehyde dehydrogenase-2 markedly contributed to age-related vascular …

The morbidity and mortality from cardiovascular diseases (CVD) remain high. Metabolic
diseases such as obesity, hyperlipidemia, diabetes mellitus (DM), non-alcoholic fatty liver …

Life began in a ferruginous (anoxic and Fe 2+ dominated) world around 3.8 billion years ago
(bya). Hydrogen sulfide (H 2 S) and other sulfur molecules from hydrothermal vents and …

Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, in late December
2019. Since then, COVID-19 has spread rapidly worldwide and was declared a global …

Thiol-based redox compounds, namely thioredoxins (Trxs), glutaredoxins (Grxs) and
peroxiredoxins (Prxs), stand as a pivotal group of proteins involved in antioxidant processes …

Heart failure is a growing health burden worldwide characterized by alterations in excitation-
contraction coupling, cardiac energetic deficit and oxidative stress. While current treatments …

Radiation-induced liver disease (RILD), also known as radiation hepatitis, is a serious side
effect of radiotherapy (RT) for hepatocellular carcinoma. The therapeutic dose of RT can …

Objective: Dysfunction of endothelial progenitor cells (EPCs) leads to impaired endothelial
repair capacity in patients with hypertension, but the mechanisms remain incompletely …