Elevated production of prostanoids from the constitutive (COX-1) or inducible (COX-2) cyclo-
oxygenases has been involved in the alterations in vascular function, structure and …

Obesity is an energy balance disorder associated with dyslipidemia, insulin resistance and
diabetes type 2, also summarized with the term metabolic syndrome or syndrome X …

Inflammation is associated with the release of soluble mediators that drive cellular activation
and migration of inflammatory leukocytes to the site of injury, together with endothelial …

Angiotensin II (Ang II) has been implicated in the pathophysiology of various age-dependent
ocular diseases. The purpose of this study was to test the hypothesis that Ang II induces …

Although oxidative agents such as free radicals can fight pathogens, an imbalance of
oxidant/anti-oxidant activity can lead to harmful effects in our body known as oxidative …

Doxorubicin (DOX) is an effective chemotherapeutic agent; however; its use is limited by
some side effects; such as cardiotoxicity and thrombocytopenia. DOX-induced cardiotoxicity …

Nitric oxide synthases (NOS) are the major sources of nitric oxide (NO), a small bioactive
molecule involved in the regulation of many cellular processes. One of the most prominent …

Alzheimer's Disease (AD) is becoming more prevalent as the population lives longer. For
individuals over 60 years of age, the prevalence of AD is estimated at 40.19% across the …

Nitro-oxidative stress and lowered antioxidant defences play a key role in neuropsychiatric
disorders such as major depression, bipolar disorder and schizophrenia. The first part of this …

Smoking tobacco cigarettes is a significant (cardiovascular) health risk factor. Although the
number of tobacco cigarette users declined over the last decades, shisha smoking and e …