Tailor made: the art of therapeutic mRNA design

M Metkar, CS Pepin, MJ Moore - Nature Reviews Drug Discovery, 2024 - nature.com
Abstract mRNA medicine is a new and rapidly developing field in which the delivery of
genetic information in the form of mRNA is used to direct therapeutic protein production in …

Tobacco as green bioreactor for therapeutic protein production: latest breakthroughs and optimization strategies

M Naeem, R Han, N Ahmad, W Zhao, L Zhao - Plant Growth Regulation, 2024 - Springer
In recent years, higher plants have emerged as intrinsic sources for generating vast
quantities of valuable therapeutic proteins to meet the demands of disease prevention or …

Analysis of synonymous codon usage patterns in mitochondrial genomes of nine Amanita species

Q Li, Y Luo, A Sha, W Xiao, Z Xiong, X Chen… - Frontiers in …, 2023 - frontiersin.org
Introduction Codon basis is a common and complex natural phenomenon observed in many
kinds of organisms. Methods In the present study, we analyzed the base bias of 12 …

Complete Chloroplast Genomes and Phylogenetic Relationships of Bougainvillea spectabilis and Bougainvillea glabra (Nyctaginaceae)

H Zhang, T Huang, Q Zhou, Q Sheng, Z Zhu - International Journal of …, 2023 - mdpi.com
Bougainvillea L.(Nyctaginaceae) is a South American native woody flowering shrub of high
ornamental, economic, and medicinal value which is susceptible to cold damage. We …

DNA-Based Nonviral Gene Therapy─ Challenging but Promising

X Guan, Y Pei, J Song - Molecular Pharmaceutics, 2024 - ACS Publications
Over the past decades, significant progress has been made in utilizing nucleic acids,
including DNA and RNA molecules, for therapeutic purposes. For DNA molecules, although …

Are genomic language models all you need? exploring genomic language models on protein downstream tasks

S Boshar, E Trop, BP de Almeida, L Copoiu… - …, 2024 - academic.oup.com
Motivation Large language models, trained on enormous corpora of biological sequences,
are state-of-the-art for downstream genomic and proteomic tasks. Since the genome …

Intraspecific and interspecific variations in the synonymous codon usage in mitochondrial genomes of 8 pleurotus strains

W Gao, X Chen, J He, A Sha, Y Luo, W Xiao, Z Xiong… - BMC genomics, 2024 - Springer
In this study, we investigated the codon bias of twelve mitochondrial core protein coding
genes (PCGs) in eight Pleurotus strains, two of which are from the same species. The results …

Nothing in evolution makes sense except in the light of code biology

R Prinz - Biosystems, 2023 - Elsevier
This article highlights the potential contribution of biological codes to the course and
dynamics of evolution. The concept of organic codes, developed by Marcello Barbieri, has …

Codon usage pattern of the ancestor of green plants revealed through Rhodophyta

H Yao, T Li, Z Ma, X Wang, L Xu, Y Zhang, Y Cai… - BMC genomics, 2023 - Springer
Rhodophyta are among the closest known relatives of green plants. Studying the codons of
their genomes can help us understand the codon usage pattern and characteristics of the …

Complete chloroplast genome sequences of the medicinal plant Aconitum transsectum (Ranunculaceae): comparative analysis and phylogenetic relationships

N Yanfei, S Tai, W Chunhua, D Jia, Y Fazhong - BMC genomics, 2023 - Springer
Abstract Background Aconitum transsectum Diels.(Ranunculaceae) is an important
medicinal plant that is widely used in traditional Chinese medicine, but its morphological …