Rationale Brain-derived neurotrophic factor (BDNF) and signaling at its receptor,
tropomyosin-related kinase B (TrkB), are implicated in the rapid and long-lasting …

Background The high-affinity N-methyl-D-aspartate (NMDA) antagonist ketamine exerts
rapid antidepressant effects but has psychotomimetic properties. AZD6765 is a low-trapping …

Severe psychiatric disorders such as schizophrenia are related to cognitive and negative
symptoms, which often are resistant to current treatment approaches. The glutamatergic …

A substantial amount of research has shown that N-methyl-D-aspartate receptors (NMDARs)
may play a key role in the pathophysiology of several neurological diseases, including …

ObjectiveAlthough monoaminergic-targeted drugs have prompted great advances in the
development of treatments for depression, the need for new options persists, since these …

Epidemiological studies have demonstrated a close relationship between depression and
cardiovascular disease (CVD). Although it is known that the central nervous system (CNS) …

Among treatments currently assessed in major depression, ketamine, has been proposed of
great interest, especially because of its very rapid action. However, the time-course of the …

Abstract Purpose of Review Studies of the neurobiology and treatment of PTSD have
highlighted many aspects of the pathophysiology of this disorder that might be relevant to …

BackgroundWhile oral antidepressants reach efficacy after weeks, single-dose intravenous
(iv) ketamine has rapid, yet time-limited antidepressant effects. We aimed to determine the …

Essential elements are very important for the proper functioning of the human body. They
are required for fundamental life processes such as cell division and differentiation and …