Depression occurs with a high prevalence of up to 50% in patients with Alzheimer's disease
(AD) and increases the caregivers' burden. Depression symptoms can precede clinical …

Background Chronic pain is associated with depression. In rodents, pain is often assessed
by sensory hypersensitivity, which does not sufficiently measure affective responses. Low …

Antagonism of N-methyl-d-aspartate glutamatergic receptors (NMDAR) may represent an
effective antidepressant mechanism. d-cycloserine (DCS) is a partial agonist at the NMDAR …

Social stress, including bullying during adolescence, is a risk factor for common
psychopathologies such as depression. To investigate the neural mechanisms associated …

The neurotransmitter glutamate is the primary excitatory neurotransmitter in mammalian
brain and is responsible for most corticocortical and corticofugal neurotransmission …

This study included 168 and 85 mother–infant dyads from Asian and United States of
America cohorts to examine whether a genomic profile risk score for major depressive …

Ketamine, a derivative of phencyclidine that was developed in the 1960s, is an anesthetic
and analgesic with hallucinogenic effects. In this paper, the pharmacological and …

BACKGROUND: N-methyl-D-aspartate receptor (NMDA-R) hypofunction plays an important
role in cognitive impairment in schizophrenia. NMDA-R antagonists elicit psychotic …

Abstract The serotonin-1A (5-HT1A) receptor is among the most abundant and widely
distributed 5-HT receptors in the brain, but is also expressed on serotonin neurons as an …

Depression is a major contributor to the global burden of disease and disability, yet it is
poorly understood. Here we review data supporting a novel theoretical model for the biology …