Objectivel-theanine, an amino acid uniquely contained in green tea (Camellia sinensis), has
been suggested to have various psychotropic effects. This study aimed to examine whether l …

Major depressive disorder (MDD) is a common, chronic, recurrent mental illness that affects
millions of individuals worldwide. Currently available antidepressants are known to affect the …

The versatility of glutamate as the brain's foremost excitatory neurotransmitter and modulator
of neurotransmission and function is considered common knowledge. Years of research …

Post-mortem histopathological studies report on reduced glial cell numbers in various
frontolimbic areas of depressed patients implying that glial loss together with abnormal …

Incomplete response to monoaminergic antidepressants in major depressive disorder
(MDD), and the phenomenon of neuroprogression, suggests a need for additional …

Depression is a salient emotional feature of chronic pain. Depression alters the pain
threshold and impairs functional recovery. To date, however, there has been limited …

Major depression is a highly prevalent disorder and is predicted to be the second leading
cause of disease burden by 2020. Although many antidepressant drugs are currently …

Background Cocaine dependence involves problematic neuroadaptations that might be
responsive to modulation of glutamatergic circuits. This investigation examined the effects of …

The efficacy of currently available medications for depression is unsatisfactory, and that has
spurred the development of novel antidepressants based on a hypothesis other than the …

Background Clinical studies demonstrate that the N-methyl-D-aspartate (NMDA) receptor
antagonist, ketamine, induces rapid antidepressant effects in patients with refractive major …