The so-called “psychedelic renaissance” has stimulated expanded interest in several
classes of drugs that appear to possess transdiagnostic effects in the treatment of mental …

Major depressive disorder is a severe and complex mental disorder. Impaired
neurotransmission and disrupted signalling pathways may influence neuroplasticity, which …

The prevalence of depression increases with aging. We hypothesized that like humans, old
animals exhibit anhedonic-like behavior, along with signs of behavioral despair. In rodents …

Major depressive disorder is among the most prevalent forms of mental illness. All currently
available antidepressant medications have stemmed from study of the mechanisms of …

Accumulating evidence suggests that the glutamatergic system plays important roles in the
pathophysiology and treatment of major depressive disorder (MDD). Abnormalities in the …

Major depressive disorder (MDD) is an emergent cause of personal and socio‐economic
burden, both for the high prevalence of the disorder and the unsatisfying response rate of …

Rationale Escitalopram is a widely used antidepressant for the treatment of patients with
major depression. It is the pure S-enantiomer of racemic citalopram. Several clinical trials …

Amino-acid neurotransmitter system dysfunction plays a major role in the pathophysiology of
major depressive disorder (MDD). We used proton magnetic resonance spectroscopy (1H …

Despite the central role PSD-95 plays in anchoring postsynaptic AMPARs, how PSD-95
itself is tethered to postsynaptic sites is not well understood. Here we show that the F-actin …

Major depression is the most common form of mental illness, and is treated with
antidepressant compounds that increase serotonin (5-HT) neurotransmission. Increased 5 …