Fatty acid synthase inhibitor orlistat impairs cell growth and down-regulates PD-L1 expression of a human T-cell leukemia line
G Cioccoloni, A Aquino, M Notarnicola… - Journal of …, 2020 - Taylor & Francis
Fatty Acid Synthase (FASN) is responsible for the de novo synthesis of fatty acids, which are
involved in the preservation of biological membrane structure, energy storage and assembly …
involved in the preservation of biological membrane structure, energy storage and assembly …
Overexpression of TOSO in CLL is triggered by B-cell receptor signaling and associated with progressive disease
Resistance toward apoptotic stimuli mediated by overexpression of antiapoptotic factors or
extracellular survival signals is considered to be responsible for accumulation of malignant …
extracellular survival signals is considered to be responsible for accumulation of malignant …
B-cell receptor triggers drug sensitivity of primary CLL cells by controlling glucosylation of ceramides
J Schwamb, V Feldhaus, M Baumann… - Blood, the journal of …, 2012 - ashpublications.org
Survival of chronic lymphocytic leukemia (CLL) cells is triggered by several stimuli, such as
the B-cell receptor (BCR), CD40 ligand (CD40L), or interleukin-4 (IL-4). We identified that …
the B-cell receptor (BCR), CD40 ligand (CD40L), or interleukin-4 (IL-4). We identified that …
Current Status of Novel Agents for the Treatment of B Cell Malignancies: What's Coming Next?
Simple Summary Since the identification of a large variety of biomarkers in B cell
malignancies as being driving factors for tumor progression and patient prognosis, their …
malignancies as being driving factors for tumor progression and patient prognosis, their …
[HTML][HTML] The PPARα agonist fenofibrate suppresses B-cell lymphoma in mice by modulating lipid metabolism
Obesity is associated with an increased risk for malignant lymphoma development. We used
Bcr/Abl transformed B cells to determine the impact of aggressive lymphoma formation on …
Bcr/Abl transformed B cells to determine the impact of aggressive lymphoma formation on …
The Role of Cholesterol in Chronic Lymphocytic Leukemia Development and Pathogenesis
AM White, OG Best, AK Hotinski, BJ Kuss, LA Thurgood - Metabolites, 2023 - mdpi.com
Cholesterol has many critical functions in cells. It is a key component of membranes and cell-
signalling processes, and it functions as a chemical precursor in several biochemical …
signalling processes, and it functions as a chemical precursor in several biochemical …
Development of a self-assembled nanoparticle formulation of orlistat, nano-ORL, with increased cytotoxicity against human tumor cell lines
Fatty acid synthase (FASN), the enzyme that catalyzes de novo synthesis of fatty acids, is
expressed in many cancer types. Its potential as a therapeutic target is well recognized, but …
expressed in many cancer types. Its potential as a therapeutic target is well recognized, but …
Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: role of cell survival regulatory molecules
BACKGROUND: De novo fatty acid synthesis catalyzed by fatty acid synthase (FASN) is
crucial for tumor cell survival. Thus therapeutic targeting of FASN is considered as a novel …
crucial for tumor cell survival. Thus therapeutic targeting of FASN is considered as a novel …
Inhibition of protein geranylgeranylation specifically interferes with CD40-dependent B cell activation, resulting in a reduced capacity to induce T cell immunity
A Shimabukuro-Vornhagen, S Zoghi… - The Journal of …, 2014 - journals.aai.org
Ab-independent effector functions of B cells, such as Ag presentation and cytokine
production, have been shown to play an important role in a variety of immune-mediated …
production, have been shown to play an important role in a variety of immune-mediated …
Gene expression profiling identifies ARSD as a new marker of disease progression and the sphingolipid metabolism as a potential novel metabolism in chronic …
A Trojani, B Di Camillo, A Tedeschi… - Cancer …, 2012 - content.iospress.com
Background: Several studies demonstrated IGVH mutational status and ZAP70 expression
as the most relevant prognostic markers in Chronic Lymphocytic Leukemia (CLL) …
as the most relevant prognostic markers in Chronic Lymphocytic Leukemia (CLL) …