Background: Sporadic colorectal cancers often arise from a region of cells characterized by
a “field defect” that has not been well defined molecularly. DNA methylation has been …

Currently available evidence from epidemiologic, animal, and intervention studies does not
unequivocally support the role of folate, a water‐soluble B vitamin and important cofactor in …

Background Fecal occult-blood testing and sigmoidoscopy have been recommended for
screening for colorectal cancer, but the sensitivity of such combined testing for detecting …

Background: Evaluating trends in colorectal cancer (CRC) screening use is critical for
understanding screening implementation, and whether population groups targeted for …

Background: Current guidelines recommend a 10-year interval between screening
colonoscopies, but evidence is limited. Objective: To assess the long-term risk for colorectal …

The past decade has seen extraordinary advances in colon cancer screening. Average-risk
screening has now been validated, and national public and professional educational efforts …

Background: Indirect evidence and modeling analyses suggest that colonoscopy may be the
most cost-effective way to screen the average-risk population for colorectal neoplasia …

This statement summarizes the current US Preventive Services Task Force (USPSTF)
recommendation on screening for colorectal cancer and the supporting scientific evidence …

Folate, a water-soluble B vitamin and important cofactor in 1-carbon transfer, is an important
nutritional factor that may modulate the development of colorectal cancer. Epidemiologic …

Colorectal Cancer Prevention 2000: Screening Recommendations of the American College of
Gastroenterology Page 1 COLORECTAL CANCER PREVENTION 2000 Colorectal Cancer …