What is nuclear factor kappa B (NF-κB) doing in and to the mitochondrion?
BC Albensi - Frontiers in cell and developmental biology, 2019 - frontiersin.org
A large body of literature supports the idea that nuclear factor kappa B (NF-κB) signaling
contributes to not only immunity, but also inflammation, cancer, and nervous system function …
contributes to not only immunity, but also inflammation, cancer, and nervous system function …
Mitochondrial DNA transcription and its regulation: an evolutionary perspective
The bacterial heritage of mitochondria, as well as its independent genome [mitochondrial
DNA (mtDNA)] and polycistronic transcripts, led to the view that mitochondrial transcriptional …
DNA (mtDNA)] and polycistronic transcripts, led to the view that mitochondrial transcriptional …
[HTML][HTML] Comparative genomics reveals the organic acid biosynthesis metabolic pathways among five lactic acid bacterial species isolated from fermented vegetables
CO Okoye, K Dong, Y Wang, L Gao, X Li, Y Wu… - New …, 2022 - Elsevier
Lactic acid bacteria (LAB) comprise a widespread bacterial group, inhabiting the niches of
fermented vegetables and capable of producing beneficial organic acids. In the present …
fermented vegetables and capable of producing beneficial organic acids. In the present …
Assessing the fitness consequences of mitonuclear interactions in natural populations
Metazoans exist only with a continuous and rich supply of chemical energy from oxidative
phosphorylation in mitochondria. The oxidative phosphorylation machinery that mediates …
phosphorylation in mitochondria. The oxidative phosphorylation machinery that mediates …
Experimental Support That Natural Selection Has Shaped the Latitudinal Distribution of Mitochondrial Haplotypes in Australian Drosophila melanogaster
Cellular metabolism is regulated by enzyme complexes within the mitochondrion, the
function of which are sensitive to the prevailing temperature. Such thermal sensitivity …
function of which are sensitive to the prevailing temperature. Such thermal sensitivity …
Vitamin D receptor regulates transcription of mitochondrial DNA and directly interacts with mitochondrial DNA and TFAM
Vitamin D receptor (VDR) is an essential transcription factor (TF) synthesized in different cell
types. We hypothesized that VDR might also act as a mitochondrial TF. We conducted the …
types. We hypothesized that VDR might also act as a mitochondrial TF. We conducted the …
Mitochondrial 16S rRNA is methylated by tRNA methyltransferase TRMT61B in all vertebrates
The mitochondrial ribosome, which translates all mitochondrial DNA (mtDNA)-encoded
proteins, should be tightly regulated pre-and post-transcriptionally. Recently, we found RNA …
proteins, should be tightly regulated pre-and post-transcriptionally. Recently, we found RNA …
The metazoan landscape of mitochondrial DNA gene order and content is shaped by selection and affects mitochondrial transcription
Mitochondrial DNA (mtDNA) harbors essential genes in most metazoans, yet the regulatory
impact of the multiple evolutionary mtDNA rearrangements has been overlooked. Here, by …
impact of the multiple evolutionary mtDNA rearrangements has been overlooked. Here, by …
The mitochondrial genome–on selective constraints and signatures at the organism, cell, and single mitochondrion levels
Natural selection acts on the phenotype. Therefore, many mistakenly expect to observe its
signatures only in the organism, while overlooking its impact on tissues, cells and …
signatures only in the organism, while overlooking its impact on tissues, cells and …
Immune system cells from COVID-19 patients display compromised mitochondrial-nuclear expression co-regulation and rewiring toward glycolysis
H Medini, A Zirman, D Mishmar - Iscience, 2021 - cell.com
Mitochondria are pivotal for bioenergetics, as well as in cellular response to viral infections.
Nevertheless, their role in COVID-19 was largely overlooked. Here, we analyzed available …
Nevertheless, their role in COVID-19 was largely overlooked. Here, we analyzed available …