Mitochondrial involvement in vertebrate speciation? The case of mito-nuclear genetic divergence in chameleons
Compatibility between the nuclear (nDNA) and mitochondrial (mtDNA) genomes is important
for organismal health. However, its significance for major evolutionary processes such as …
for organismal health. However, its significance for major evolutionary processes such as …
Initiation of mtDNA transcription is followed by pausing, and diverges across human cell types and during evolution
Mitochondrial DNA (mtDNA) genes are long known to be cotranscribed in polycistrones, yet
it remains impossible to study nascent mtDNA transcripts quantitatively in vivo using existing …
it remains impossible to study nascent mtDNA transcripts quantitatively in vivo using existing …
Mechanisms of mammalian mitochondrial transcription
E Bouda, A Stapon, M Garcia‐Diaz - Protein Science, 2019 - Wiley Online Library
Numerous age‐related human diseases have been associated with deficiencies in cellular
energy production. Moreover, genetic alterations resulting in mitochondrial dysfunction are …
energy production. Moreover, genetic alterations resulting in mitochondrial dysfunction are …
Mitonuclear interactions in the maintenance of mitochondrial integrity
P Karakaidos, T Rampias - Life, 2020 - mdpi.com
In eukaryotic cells, mitochondria originated in an α-proteobacterial endosymbiont. Although
these organelles harbor their own genome, the large majority of genes, originally encoded …
these organelles harbor their own genome, the large majority of genes, originally encoded …
Could Amyloid-β 1–42 or α-Synuclein Interact Directly with Mitochondrial DNA? A Hypothesis
The amyloid β (Aβ) and the α-synuclein (α-syn) are shown to be translocated into
mitochondria. Even though their roles are widely investigated in pathological conditions …
mitochondria. Even though their roles are widely investigated in pathological conditions …
Ancient out-of-Africa mitochondrial DNA variants associate with distinct mitochondrial gene expression patterns
Mitochondrial DNA (mtDNA) variants have been traditionally used as markers to trace
ancient population migrations. Although experiments relying on model organisms and …
ancient population migrations. Although experiments relying on model organisms and …
Mitochondrial heteroplasmy in vertebrates using ChIP-sequencing data
Background Mitochondrial heteroplasmy, the presence of more than one mitochondrial DNA
(mtDNA) variant in a cell or individual, is not as uncommon as previously thought. It is mostly …
(mtDNA) variant in a cell or individual, is not as uncommon as previously thought. It is mostly …
Mitochondria are fundamental for the emergence of metazoans: On metabolism, genomic regulation, and the birth of complex organisms
Out of many intracellular bacteria, only the mitochondria and chloroplasts abandoned their
independence billions of years ago and became endosymbionts within the host eukaryotic …
independence billions of years ago and became endosymbionts within the host eukaryotic …
Mitochondrial nucleoid in cardiac homeostasis: bidirectional signaling of mitochondria and nucleus in cardiac diseases
Metabolic function and energy production in eukaryotic cells are regulated by mitochondria,
which have been recognized as the intracellular 'powerhouses' of eukaryotic cells for their …
which have been recognized as the intracellular 'powerhouses' of eukaryotic cells for their …
Higher order organization of the mtDNA: beyond mitochondrial transcription factor A
The higher order organization of eukaryotic and prokaryotic genomes is pivotal in the
regulation of gene expression. Specifically, chromatin accessibility in eukaryotes and …
regulation of gene expression. Specifically, chromatin accessibility in eukaryotes and …