To survive, cancer cells must resist numerous internal and environmental insults associated
with neoplasia that jeopardize proteostasis within the endoplasmic reticulum (ER). Solid and …

MicroRNAs (miRNA) are small non-coding RNAs (∼ 22 nt in length) that are known as
potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a …

Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response
(UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and …

Organ-specific metastasis is the primary cause of cancer patient death. The distant
metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of …

Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality
control to maintain homeostasis under different conditions and disease states characterized …

Arsenic exposure in contaminated drinking water is a global health issue, as more than 200
million people are affected globally. Arsenic has been known to cause skin, liver, lung …

Cancer constitutes a grave problem nowadays in view of the fact that it has become one of
the main causes of death worldwide. Poor clinical prognosis is presumably due to cancer …

In eukaryotic cells, oxidative protein folding occurs in the lumen of the endoplasmic
reticulum (ER), catalyzed by ER sulfhydryl oxidase 1 (Ero1) and protein disulfide isomerase …

Cellular reactive oxygen species (ROS) status is stabilized by a balance of ROS generation
and elimination called redox homeostasis. ROS is increased by activation of endoplasmic …

Mitochondrial dynamics can regulate Major Histocompatibility Complex (MHC)-I antigen
expression by cancer cells and their immunogenicity in mice and in patients with …