Pyroptosis, apoptosis, and necroptosis are mainly programmed cell death (PCD) pathways
for host defense and homeostasis. PANoptosis is a newly distinct inflammatory PCD …

Over 20 years ago, the pyrrolysine encoding translation system was discovered in specific
archaea. Our Review provides an overview of how the once obscure pyrrolysyl-tRNA …

The druggable proteome refers to proteins that can bind to small molecules with appropriate
chemical affinity, inducing a favorable clinical response. Predicting druggable proteins …

Survivin is a member of the family of inhibitors of apoptosis proteins (IAPs). It is involved in
the normal mitotic process and acts as an anti-apoptotic molecule. While terminally …

The tumor suppressor p53 plays a crucial role in cellular responses to various stresses,
regulating key processes such as apoptosis, senescence, and DNA repair. Dysfunctional …

The selective interaction of nanomaterials with proteins for protein function suppression has
been reported. However, whether the nanomaterials could be used to target a three …

Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

Abstract KRAS G12C mutations in non-small cell lung cancer (NSCLC) partially respond to
KRAS G12C covalent inhibitors. However, early adaptive resistance occurs due to rewiring …

Adopting computational tools for analyzing extensive biological datasets has profoundly
transformed our understanding and interpretation of biological phenomena. Innovative …

Citrullination plays an essential role in various physiological or pathological processes,
however, whether citrullination is involved in regulating tumour progression and the …