Challenges in developing personalized neoantigen cancer vaccines

PD Katsikis, KJ Ishii, C Schliehe - Nature Reviews Immunology, 2024 - nature.com
The recent success of cancer immunotherapies has highlighted the benefit of harnessing the
immune system for cancer treatment. Vaccines have a long history of promoting immunity to …

Adjuvant physiochemistry and advanced nanotechnology for vaccine development

H Ren, W Jia, Y Xie, M Yu, Y Chen - Chemical Society Reviews, 2023 - pubs.rsc.org
Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …

Harnessing engineered immune cells and bacteria as drug carriers for cancer immunotherapy

J Jiang, Y Huang, Z Zeng, C Zhao - ACS nano, 2023 - ACS Publications
Immunotherapy continues to be in the spotlight of oncology therapy research in the past few
years and has been proven to be a promising option to modulate one's innate and adaptive …

Metal-based nano-vaccines for cancer immunotherapy

J Li, H Ren, Y Zhang - Coordination Chemistry Reviews, 2022 - Elsevier
Cancer vaccination is an effective way to prevent or cure cancers by inducing strong cellular
and humoral immunity with the aid of delivery carriers or adjuvants. Increasing new delivery …

Understanding structure–function relationships of nanoadjuvants for enhanced cancer vaccine efficacy

J Tan, B Ding, B Teng, P Ma… - Advanced Functional …, 2022 - Wiley Online Library
Adjuvant, as an important part of vaccines, can observably enhance the magnitude, breadth
and durability of immune responses. Nanoadjuvants, as novel vaccine adjuvants, have …

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice

MT Mabrouk, K Chiem, E Rujas, WC Huang… - Science …, 2021 - science.org
The COVID-19 pandemic has spurred interest in potent and thermostable SARS-CoV-2
vaccines. Here, we assess low-dose immunization with lyophilized nanoparticles decorated …

Nanovaccines for cancer immunotherapy: current knowledge and future perspectives

Y Wu, Z Zhang, Y Wei, Z Qian, X Wei - Chinese Chemical Letters, 2023 - Elsevier
Cancer immunotherapy harnesses the immune system to attack tumors and has received
extensive attention in recent years. Cancer vaccines as an important branch of …

Vaccines in breast cancer: challenges and breakthroughs

GN Fatima, H Fatma, SK Saraf - Diagnostics, 2023 - mdpi.com
Breast cancer is a problem for women's health globally. Early detection techniques come in
a variety of forms ranging from local to systemic and from non-invasive to invasive. The …

Intranasal immunization with liposome-displayed receptor-binding domain induces mucosal immunity and protection against SARS-CoV-2

WC Huang, K Chiem, L Martinez-Sobrido, JF Lovell - Pathogens, 2022 - mdpi.com
The global pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), has led to efforts in developing effective vaccine approaches. Currently, approved …

Spherical nucleic acid vaccine structure markedly influences adaptive immune responses of clinically utilized prostate cancer targets

MH Teplensky, JW Dittmar, L Qin… - Advanced …, 2021 - Wiley Online Library
Cancer vaccines, which activate the immune system against a target antigen, are attractive
for prostate cancer, where multiple upregulated protein targets are identified. However …