Different cell types, equipped with unique structure and function, synthesize different sets of
proteins on the basis of different patterns of gene expression, even though their genomes …

Following gastrulation and establishment of the three embryonic germ layers, the first
definitive organ to form in the embryo is the heart, whose morphogenesis, growth, and …

We compared gene expression profiles of mouse and human ES cells by
immunocytochemistry, RT-PCR, and membrane-based focused cDNA array analysis …

A finite number of transcription factors constitute a combinatorial code that orchestrates
cardiac development and the specification and differentiation of myocytes. Many, if not all of …

Members of the Twist-family of bHLH proteins play a pivotal role in a number of essential
developmental programs. Twist-family bHLH proteins function by dimerizing with other …

Regulation of gene expression is central to cell growth, differentiation and diseases. Context
specific and signal dependent regulation of gene expression is achieved to a large part by …

Congenital heart defects account for 1% of infant mortality and 10% of in utero deaths. As
the vertebrate embryo develops, multiple tissue types develop in tandem to morphologically …

Drosophila melanogaster has become one of the important model systems to investigate the
development and differentiation of the heart. After 24h after egg deposition (h AED), a simple …

Background—Network analysis techniques allow a more accurate reflection of underlying
systems biology to be realized than traditional unidimensional molecular biology …

The HAND subclass of basic Helix–loop–helix factors is comprised of two members HAND1
and HAND2. HAND genes are present within the genomes of organisms ranging from flies …