The brain, long thought to be isolated from the peripheral immune system, is increasingly
recognized to be integrated into a systemic immunological network. These conduits of …

Simple Summary Adoptive immunotherapy has emerged as an effective alternative of
mounting impact to the current standard of care in cancer, viral infections, and recently …

Forkhead box P3 (FOXP3) is an essential transcription factor for regulatory T cell (Treg)
function. Defects in Tregs mediate many immune diseases including the monogenic …

Chimeric antigen receptor (CAR)-immune cell therapy has revolutionized the anti-tumor
field, achieving efficient and precise tumor clearance by directly guiding immune cell activity …

Despite major progress in the treatment of autoimmune diseases in the past two decades,
most therapies do not cure disease and can be associated with increased risk of infection …

Chronic obstructive pulmonary disease (COPD) is caused by smoking, but only a small
proportion of smokers have disease severe enough to develop COPD. COPD is not always …

Current treatment options for autoimmune disease (AID) are essentially
immunosuppressive, inhibiting the inflammatory cascade, without curing the disease …

Adeno-associated virus (AAV) gene therapy is making rapid strides owing to its wide range
of therapeutic applications. However, development of serious immune responses to the …

Regulatory T cells (Tregs), a suppressive subpopulation of T cells, are potent mediators of
peripheral tolerance, responsible for immune homeostasis. Many autoimmune diseases …

Objective To study whether subcutaneously embedding xenogeneic protein threads or
synthetic polymer absorbable threads can improve obesity phenotypes and metabolic …