The physiological processes of cell growth, proliferation, differentiation, and apoptosis are
closely related to STAT3, and it has been demonstrated that aberrant STAT3 expression has …

Hypertensive heart disease constitutes functional and structural dysfunction and
pathogenesis occurring primarily in the left ventricle, the left atrium and the coronary arteries …

Various types of fungicides, especially triazole fungicides, are used to prevent fungal
diseases on farmlands. However, the developmental toxicity of one of the triazole fungicides …

Background Sepsis-induced heart injury is one of the leading causes of circulation disorders
worldwide. Dapagliflozin, a sodium-glucose cotransporter 2 inhibitor mainly used for …

As major public health concerns associated with a rapidly growing aging population,
neurodegenerative diseases (NDDs) and neurological diseases are important causes of …

Cardiac remodeling is a common consequence of cardiovascular diseases and is closely
associated with oxidative stress, inflammation, and apoptosis. Germacrone, a bioactive …

Background Despite major advances in pharmacological treatment for patients with heart
failure, residual mortality remains high. This suggests that important pathways are not yet …

Doxorubicin is a potent chemotherapeutic agent that can cause cardiotoxicity. Many
documents (more than 14,000) have been published in the area of doxorubicin-induced …

Abstract The phosphatidylinositol 3‐kinase (PI3K)/AKT signaling pathway plays a central
role in cell growth and survival and is disturbed in various pathologies. The PI3K is a kinase …

Background. Cardiovascular disease (CVD) is the combination of coronary heart disease,
myocardial infarction, rheumatic heart disease, and peripheral vascular disease of the heart …