Once thought to result from passive precipitation of calcium and phosphate, it now appears
that vascular calcification is a consequence of tightly regulated processes that culminate in …

Vascular calcification, long thought to result from passive degeneration, involves a complex,
regulated process of biomineralization resembling osteogenesis. Evidence indicates that …

Background—To test the hypothesis of general atherosclerotic plaque destabilization during
acute coronary syndrome (ACS), the present study sought to analyze the 3 coronary arteries …

Background—The results of studies of advanced lesions of atherosclerosis suggest that the
thickness of the fibrous cap that overlies the necrotic core distinguishes the stable lesion …

Background We have previously reported a virtual absence of neointimal hyperplasia 4
months after implantation of sirolimus-eluting stents. The aim of the present investigation …

Plaque development and rupture are hallmarks of atherosclerotic vascular disease. Despite
current therapeutic developments, there is an unmet necessity in the prevention of …

Background—High-resolution MRI has the potential to noninvasively image the human
coronary artery wall and define the degree and nature of coronary artery disease. Coronary …

Clinical complications of atherosclerosis arise primarily as a result of luminal obstruction due
to atherosclerotic plaque growth, with inadequate outward vessel remodeling and plaque …

Objective—The importance of the extracellular matrix molecules versican, biglycan, decorin,
and hyaluronan in plaque instability has not been recognized. Methods and Results …

Atherosclerosis is the main cause of coronary heart disease, which is today the leading
cause of death worldwide and will continue to be the first in the world in 2030. In the …