[HTML][HTML] Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities

Y Wen, J Lambrecht, C Ju, F Tacke - Cellular & molecular immunology, 2021 - nature.com
Macrophages, which are key cellular components of the liver, have emerged as essential
players in the maintenance of hepatic homeostasis and in injury and repair processes in …

[HTML][HTML] Beyond hemostasis: platelet innate immune interactions and thromboinflammation

J Mandel, M Casari, M Stepanyan, A Martyanov… - International journal of …, 2022 - mdpi.com
There is accumulating evidence that platelets play roles beyond their traditional functions in
thrombosis and hemostasis, eg, in inflammatory processes, infection and cancer, and that …

[HTML][HTML] How we treat primary immune thrombocytopenia in adults

X Liu, Y Hou, M Hou - Journal of Hematology & Oncology, 2023 - Springer
Primary immune thrombocytopenia (ITP) is an immune-mediated bleeding disorder
characterized by decreased platelet counts and an increased risk of bleeding. Multiple …

The interplay between PEGylated nanoparticles and blood immune system

C Guo, H Yuan, Y Wang, Y Feng, Y Zhang, T Yin… - Advanced Drug Delivery …, 2023 - Elsevier
During the last two decades, an increasing number of reports have pointed out that the
immunogenicity of polyethylene glycol (PEG) may trigger accelerated blood clearance …

[HTML][HTML] Endocrine role of bone in the regulation of energy metabolism

R Zhou, Q Guo, Y Xiao, Q Guo, Y Huang, C Li, X Luo - Bone research, 2021 - nature.com
Abstracts Bone mainly functions as a supportive framework for the whole body and is the
major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing …

[HTML][HTML] Platelet activation mechanisms and consequences of immune thrombocytopenia

S Sun, RT Urbanus, H Ten Cate, PG de Groot… - Cells, 2021 - mdpi.com
Autoimmune disorders are often associated with low platelet count or thrombocytopenia. In
immune-induced thrombocytopenia (IIT), a common mechanism is increased platelet …

[HTML][HTML] The phagocytic code regulating phagocytosis of mammalian cells

TOJ Cockram, JM Dundee, AS Popescu… - Frontiers in …, 2021 - frontiersin.org
Mammalian phagocytes can phagocytose (ie eat) other mammalian cells in the body if they
display certain signals, and this phagocytosis plays fundamental roles in development, cell …

[HTML][HTML] Crosstalk between platelets and microbial pathogens

C Li, J Li, H Ni - Frontiers in immunology, 2020 - frontiersin.org
Platelets, small anucleate cells circulating in the blood, are critical mediators in haemostasis
and thrombosis. Interestingly, recent studies demonstrated that platelets contain both pro …

[HTML][HTML] Kupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice

Y Jiang, Y Tang, C Hoover, Y Kondo, D Huang… - Cell Death & …, 2021 - nature.com
The liver has recently been identified as a major organ for destruction of desialylated
platelets. However, the underlying mechanism remains unclear. Kupffer cells, which are …

Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria

H An, C Qian, Y Huang, J Li, X Tian, J Feng… - Journal of Experimental …, 2022 - rupress.org
Many encapsulated bacteria use capsules to cause invasive diseases. However, it remains
largely unknown how the capsules enhance bacterial virulence under in vivo infection …