A healthy aorta exerts a powerful cushioning function, which limits arterial pulsatility and
protects the microvasculature from potentially harmful fluctuations in pressure and blood …

Outcomes for heart failure (HF) patients remain suboptimal. No known therapy improves
mortality in acute HF and HF with preserved ejection fraction; the most recent HF trial results …

Townsend et al Vascular Research on Arterial Stiffness 699 pressure, blood flow, and
arterial diameter change with each heartbeat. In addition to the passive mechanical …

Heart failure with preserved ejection fraction (HFpEF) involves multiple pathophysiological
mechanisms, which result in the heterogeneous phenotypes that are evident clinically, and …

Objectives: This study sought to assess sex differences in ventricular-arterial interactions.
Background: Heart failure with preserved ejection fraction is more prevalent in women than …

Due to the cyclic function of the human heart, pressure and flow in the circulation are
pulsatile rather than continuous. Addressing pulsatile haemodynamics starts with the most …

The prevalence of HFpEF is increasing and women outnumber men by a 2: 1 ratio. Recent
data have identified striking parallels between structure–function alterations observed in …

Aortic stiffness increases with advancing age, more than doubling during the human life
span, and is a robust predictor of cardiovascular disease (CVD) clinical events independent …

Increased arterial stiffness and wave reflection have been reported in heart failure with
normal ejection fraction (HFNEF) and in asymptomatic left ventricular (LV) diastolic …

Aortic stiffness increases markedly with age and is associated with excess risk for various
adverse clinical outcomes, including heart disease, dementia, and kidney disease. Although …