Nearly all deaths caused by solid cancers occur as a result of metastasis—the formation of
secondary tumours in distant organs such as the lungs, liver, brain and bone. A major …

Current clinical management of breast cancer relies on the availability of robust
clinicopathological variables and few well-defined biological markers. Recent microarray …

Although metastasis is the leading cause of cancer-related death, it is not clear why some
patients with localized cancer develop metastatic disease after complete resection of their …

Abstract Background Circulating tumor cells (CTCs) have long been considered a reflection
of tumor aggressiveness. Hematogenous spreading of CTCs from a primary tumor is a …

Triple-negative breast cancer (TNBC) is currently the most malignant subtype of breast
cancers without effective targeted therapies. Mifepristone (MIF), a drug regularly used for …

DNA repair pathways can enable tumor cells to survive DNA damage induced by
chemotherapy and thus provide prognostic and/or predictive value. We evaluated Affymetrix …

Predictive data mining in clinical medicine deals with learning models to predict patients'
health. The models can be devoted to support clinicians in diagnostic, therapeutic, or …

Cancer is a heterogeneous and complex disease. Tumors are formed by cancer cells and a
myriad of non-cancerous cell types that together with the extracellular matrix form the tumor …

Background and Methods Formalin Fixed Paraffin Embedded (FFPE) samples represent a
valuable resource for cancer research. However, the discovery and development of new …

Breast cancer is a heterogeneous disease with a complex etiology that develops from
different cellular lineages, progresses along multiple molecular pathways, and demonstrates …