New concepts for an old problem: the diagnosis of endometrial hyperplasia
PA Sanderson, HOD Critchley… - Human reproduction …, 2017 - academic.oup.com
BACKGROUND Endometrial hyperplasia (EH) is a uterine pathology representing a
spectrum of morphological endometrial alterations. It is predominantly characterized by an …
spectrum of morphological endometrial alterations. It is predominantly characterized by an …
[HTML][HTML] Notch and interacting signalling pathways in cardiac development, disease, and regeneration
D MacGrogan, J Münch, JL de la Pompa - Nature Reviews Cardiology, 2018 - nature.com
Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …
[HTML][HTML] Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation
In vertebrate hearts, the ventricular trabecular myocardium develops as a sponge-like
network of cardiomyocytes that is critical for contraction and conduction, ventricular …
network of cardiomyocytes that is critical for contraction and conduction, ventricular …
Endocardial Notch signaling in cardiac development and disease
The Notch signaling pathway is an ancient and highly conserved signaling pathway that
controls cell fate specification and tissue patterning in the embryo and in the adult. Region …
controls cell fate specification and tissue patterning in the embryo and in the adult. Region …
Cardiac regeneration: lessons from development
Palliative surgery for congenital heart disease has allowed patients with previously lethal
heart malformations to survive and, in most cases, to thrive. However, these procedures …
heart malformations to survive and, in most cases, to thrive. However, these procedures …
[HTML][HTML] Endocardial Notch signaling promotes cardiomyocyte proliferation in the regenerating zebrafish heart through Wnt pathway antagonism
L Zhao, R Ben-Yair, CE Burns, CG Burns - Cell reports, 2019 - cell.com
Previous studies demonstrate that the regenerative zebrafish heart responds to injury by
upregulating Notch receptors in the endocardium and epicardium. Moreover, global …
upregulating Notch receptors in the endocardium and epicardium. Moreover, global …
Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations
The newt and the zebrafish have the ability to regenerate many of their tissues and organs
including the heart. Thus, a major goal in experimental medicine is to elucidate the …
including the heart. Thus, a major goal in experimental medicine is to elucidate the …
[HTML][HTML] Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity
Objective/methods DNA methylation plays an important role in obesity and related metabolic
complications. We examined genome-wide DNA promoter methylation along with mRNA …
complications. We examined genome-wide DNA promoter methylation along with mRNA …
[HTML][HTML] Direct reprogramming induces vascular regeneration post muscle ischemic injury
Reprogramming non-cardiomyocytes (non-CMs) into cardiomyocyte (CM)-like cells is a
promising strategy for cardiac regeneration in conditions such as ischemic heart disease …
promising strategy for cardiac regeneration in conditions such as ischemic heart disease …
The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2
X Han, J Zhang, Y Liu, X Fan, S Ai, Y Luo, X Li… - …, 2019 - journals.biologists.com
Exploration and dissection of potential actions and effects of long noncoding RNA (lncRNA)
in animals remain challenging. Here, using multiple knockout mouse models and single cell …
in animals remain challenging. Here, using multiple knockout mouse models and single cell …