BACKGROUND Endometrial hyperplasia (EH) is a uterine pathology representing a
spectrum of morphological endometrial alterations. It is predominantly characterized by an …

Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

In vertebrate hearts, the ventricular trabecular myocardium develops as a sponge-like
network of cardiomyocytes that is critical for contraction and conduction, ventricular …

The Notch signaling pathway is an ancient and highly conserved signaling pathway that
controls cell fate specification and tissue patterning in the embryo and in the adult. Region …

Palliative surgery for congenital heart disease has allowed patients with previously lethal
heart malformations to survive and, in most cases, to thrive. However, these procedures …

Previous studies demonstrate that the regenerative zebrafish heart responds to injury by
upregulating Notch receptors in the endocardium and epicardium. Moreover, global …

The newt and the zebrafish have the ability to regenerate many of their tissues and organs
including the heart. Thus, a major goal in experimental medicine is to elucidate the …

Objective/methods DNA methylation plays an important role in obesity and related metabolic
complications. We examined genome-wide DNA promoter methylation along with mRNA …

Reprogramming non-cardiomyocytes (non-CMs) into cardiomyocyte (CM)-like cells is a
promising strategy for cardiac regeneration in conditions such as ischemic heart disease …

Exploration and dissection of potential actions and effects of long noncoding RNA (lncRNA)
in animals remain challenging. Here, using multiple knockout mouse models and single cell …