Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …
Pathogenesis of osteoarthritis: risk factors, regulatory pathways in chondrocytes, and experimental models
Y He, Z Li, PG Alexander, BD Ocasio-Nieves, L Yocum… - Biology, 2020 - mdpi.com
As the most common chronic degenerative joint disease, osteoarthritis (OA) is the leading
cause of pain and physical disability, affecting millions of people worldwide. Mainly …
cause of pain and physical disability, affecting millions of people worldwide. Mainly …
Exosomes derived from miR-126-3p-overexpressing synovial fibroblasts suppress chondrocyte inflammation and cartilage degradation in a rat model of osteoarthritis
Y Zhou, J Ming, Y Li, B Li, M Deng, Y Ma, Z Chen… - Cell Death …, 2021 - nature.com
MicroRNAs (miRNAs) encapsulated within exosomes can serve as essential regulators of
intercellular communication and represent promising biomarkers of several aging …
intercellular communication and represent promising biomarkers of several aging …
Molecular classification of knee osteoarthritis
Z Lv, YX Yang, J Li, Y Fei, H Guo, Z Sun, J Lu… - Frontiers in cell and …, 2021 - frontiersin.org
Knee osteoarthritis (KOA) is the most common form of joint degeneration with increasing
prevalence and incidence in recent decades. KOA is a molecular disorder characterized by …
prevalence and incidence in recent decades. KOA is a molecular disorder characterized by …
Regulation and therapy, the role of JAK2/STAT3 signaling pathway in OA: a systematic review
B Chen, K Ning, M Sun, X Zhang - Cell Communication and Signaling, 2023 - Springer
Osteoarthritis (OA) is a multifactorial chronic disease primarily characterized by the
degeneration of articular cartilage. Currently, there is a lack of effective treatments for OA …
degeneration of articular cartilage. Currently, there is a lack of effective treatments for OA …
Role of MicroRNA, LncRNA, and exosomes in the progression of osteoarthritis: a review of recent literature
F Xie, Y Liu, X Chen, Q Li, J Zhong, B Dai… - Orthopaedic …, 2020 - Wiley Online Library
Osteoarthritis (OA) is a common clinical degenerative disease characterized by the
destruction of articular cartilage, which has an increasing impact on people's lives and social …
destruction of articular cartilage, which has an increasing impact on people's lives and social …
Overexpression of FTO alleviates osteoarthritis by regulating the processing of miR-515-5p and the TLR4/MyD88/NF-κB axis
D Cai, J Zhang, J Yang, Q Lv, C Zhong - International …, 2023 - Elsevier
Objective Osteoarthritis (OA) is regarded as the most prevalent chronic joint disease. Fat-
mass and obesity-associated gene (FTO) is involved in OA alleviation. This study elucidated …
mass and obesity-associated gene (FTO) is involved in OA alleviation. This study elucidated …
Human bone mesenchymal stem cells-derived exosomal miRNA-361-5p alleviates osteoarthritis by downregulating DDX20 and inactivating the NF-κB signaling …
Y Tao, J Zhou, Z Wang, H Tao, J Bai, G Ge, W Li… - Bioorganic …, 2021 - Elsevier
Osteoarthritis (OA) is a chronic disease featured by joint hyperplasia, deterioration of
articular cartilage, and progressive degeneration. Abnormal expression of microRNAs …
articular cartilage, and progressive degeneration. Abnormal expression of microRNAs …
CircRNA_0092516 regulates chondrocyte proliferation and apoptosis in osteoarthritis through the miR-337-3p/PTEN axis
Z Huang, W Ma, J Xiao, X Dai… - The journal of …, 2021 - academic.oup.com
The dysregulation of circular RNAs (circRNAs) has been identified in various human
diseases. Here, we probed into the potential mechanism of circRNA_0092516 in …
diseases. Here, we probed into the potential mechanism of circRNA_0092516 in …
Inflammatory and metabolic signaling interfaces of the hypertrophic and senescent chondrocyte phenotypes associated with osteoarthritis
Osteoarthritis (OA) is a complex disease of whole joints with progressive cartilage matrix
degradation and chondrocyte transformation. The inflammatory features of OA are reflected …
degradation and chondrocyte transformation. The inflammatory features of OA are reflected …