During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …

The continued emergence of novel viruses poses a significant threat to global health.
Uncontrolled outbreaks can result in pandemics that have the potential to overburden our …

The great majority of globally circulating pathogens go undetected, undermining patient care
and hindering outbreak preparedness and response. To enable routine surveillance and …

A cure for HIV-1 remains unattainable as only one case has been reported, a decade ago,.
The individual—who is known as the 'Berlin patient'—underwent two allogeneic …

Background Understanding the patterns of HIV/AIDS epidemics is crucial to tracking and
monitoring the progress of prevention and control efforts in countries. We provide a …

Background An efavirenz-based regimen (with a 600-mg dose of efavirenz, known as
EFV600) was the World Health Organization preferred first-line treatment for human …

Background Updated WHO guidelines recommend a dolutegravir-based regimen as the
preferred first-line treatment for HIV infection and low-dose efavirenz (400 mg) as an …

Background Contemporary antiretroviral therapies (ART) and management strategies have
diminished both human immunodeficiency virus (HIV) treatment failure and the acquired …

Background Due to the high prevalence of resistance to NNRTI-based ART since 2018,
consolidated recommendations from the WHO have indicated dolutegravir as the preferred …

Background Late initiation of HIV antiretroviral therapy (ART) in pregnancy is associated
with not achieving viral suppression before giving birth and increased mother-to-child …