Single-cell quantification of a broad RNA spectrum reveals unique noncoding patterns associated with cell types and states
The ability to interrogate total RNA content of single cells would enable better mapping of
the transcriptional logic behind emerging cell types and states. However, current single-cell …
the transcriptional logic behind emerging cell types and states. However, current single-cell …
Long noncoding RNAs: fresh perspectives into the RNA world
L Yang, JE Froberg, JT Lee - Trends in biochemical sciences, 2014 - cell.com
Large-scale mapping of transcriptomes has revealed significant levels of transcriptional
activity within both unannotated and annotated regions of the genome. Interestingly, many of …
activity within both unannotated and annotated regions of the genome. Interestingly, many of …
Functional annotation of human long noncoding RNAs via molecular phenotyping
Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian
genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project …
genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project …
The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing
G Barry, JA Briggs, DP Vanichkina, EM Poth… - Molecular …, 2014 - nature.com
Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning.
Although defective alternative splicing has been linked to SZ, the molecular mechanisms …
Although defective alternative splicing has been linked to SZ, the molecular mechanisms …
LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis
P Hou, Y Zhao, Z Li, R Yao, M Ma, Y Gao, L Zhao… - Cell death & …, 2014 - nature.com
LncRNAs have critical roles in various biological processes ranging from embryonic
development to human diseases, including cancer progression, although their detailed …
development to human diseases, including cancer progression, although their detailed …
Organizing principles of mammalian nonsense-mediated mRNA decay
MWL Popp, LE Maquat - Annual review of genetics, 2013 - annualreviews.org
Cells use messenger RNAs (mRNAs) to ensure the accurate dissemination of genetic
information encoded by DNA. Given that mRNAs largely direct the synthesis of a critical …
information encoded by DNA. Given that mRNAs largely direct the synthesis of a critical …
Transposable elements reveal a stem cell-specific class of long noncoding RNAs
Background Numerous studies over the past decade have elucidated a large set of long
intergenic noncoding RNAs (lincRNAs) in the human genome. Research since has shown …
intergenic noncoding RNAs (lincRNAs) in the human genome. Research since has shown …
[HTML][HTML] Progress toward understanding chromosome silencing by Xist RNA
N Brockdorff, JS Bowness, G Wei - Genes & development, 2020 - genesdev.cshlp.org
The X inactive-specific transcript (Xist) gene is the master regulator of X chromosome
inactivation in mammals. Xist produces a long noncoding (lnc) RNA that accumulates over …
inactivation in mammals. Xist produces a long noncoding (lnc) RNA that accumulates over …
Suppression of progenitor differentiation requires the long noncoding RNA ANCR
M Kretz, DE Webster, RJ Flockhart, CS Lee… - Genes & …, 2012 - genesdev.cshlp.org
Long noncoding RNAs (lncRNAs) regulate diverse processes, yet a potential role for
lncRNAs in maintaining the undifferentiated state in somatic tissue progenitor cells remains …
lncRNAs in maintaining the undifferentiated state in somatic tissue progenitor cells remains …
Transcriptomics in the RNA-seq era
PA McGettigan - Current opinion in chemical biology, 2013 - Elsevier
The transcriptomics field has developed rapidly with the advent of next-generation
sequencing technologies. RNA-seq has now displaced microarrays as the preferred method …
sequencing technologies. RNA-seq has now displaced microarrays as the preferred method …