N 6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential
Previous studies have revealed the critical roles of N 6-methyladenosine (m6A) modification
of mRNA in embryonic stem cells (ESCs), but the biological function of m6A in large …
of mRNA in embryonic stem cells (ESCs), but the biological function of m6A in large …
[HTML][HTML] Emerging roles of lncRNAs in the post-transcriptional regulation in cancer
RZ He, DX Luo, YY Mo - Genes & diseases, 2019 - Elsevier
Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal
role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master …
role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master …
Long noncoding RNAs and microRNAs in cardiovascular pathophysiology
T Thum, G Condorelli - Circulation research, 2015 - Am Heart Assoc
RNAs not encoding proteins have gained prominence over the last couple of decades as
fundamental regulators of cellular function. Not surprisingly, their dysregulation is …
fundamental regulators of cellular function. Not surprisingly, their dysregulation is …
The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity
Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements
expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the …
expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the …
Targeting long non-coding RNA to therapeutically upregulate gene expression
C Wahlestedt - Nature reviews Drug discovery, 2013 - nature.com
The majority of currently available drugs and tool compounds exhibit an inhibitory
mechanism of action and there is a relative lack of pharmaceutical agents that are capable …
mechanism of action and there is a relative lack of pharmaceutical agents that are capable …
Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis
Long noncoding RNAs (lncRNAs) comprise a diverse class of transcripts that structurally
resemble mRNAs but do not encode proteins. Recent genome-wide studies in humans and …
resemble mRNAs but do not encode proteins. Recent genome-wide studies in humans and …
[PDF][PDF] A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer
In a genome-wide survey on somatic copy-number alterations (SCNAs) of long noncoding
RNA (lncRNA) in 2,394 tumor specimens from 12 cancer types, we found that about 21.8 …
RNA (lncRNA) in 2,394 tumor specimens from 12 cancer types, we found that about 21.8 …
The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response
H Lin, M Jiang, L Liu, Z Yang, Z Ma, S Liu, Y Ma… - Nature …, 2019 - nature.com
The helicase RIG-I initiates an antiviral immune response after recognition of pathogenic
RNA. TRIM25, an E3 ubiquitin ligase, mediates K63-linked ubiquitination of RIG-I, which is …
RNA. TRIM25, an E3 ubiquitin ligase, mediates K63-linked ubiquitination of RIG-I, which is …
Non-coding RNAs in human disease
M Esteller - Nature reviews genetics, 2011 - nature.com
The relevance of the non-coding genome to human disease has mainly been studied in the
context of the widespread disruption of microRNA (miRNA) expression and function that is …
context of the widespread disruption of microRNA (miRNA) expression and function that is …
A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics
Pseudogenes are thought to be inactive gene sequences, but recent evidence of extensive
pseudogene transcription raised the question of potential function. Here we discover and …
pseudogene transcription raised the question of potential function. Here we discover and …