Decreased sequencing costs have led to an explosion of genetic and genomic data. These
data have revealed thousands of candidate human disease variants. Establishing which …

Usher syndrome (USH) is an autosomal recessive syndromic ciliopathy characterized by
sensorineural hearing loss, retinitis pigmentosa and, sometimes, vestibular dysfunction …

The brain-derived neurotrophic factor (BDNF) was discovered in the last century, and
identified as a member of the neurotrophin family. BDNF shares approximately 50% of its …

The perfluorooctane sulfonate alternative, F–53B, induces multiple physiological defects but
whether it can disrupt eye development is unknown. We exposed zebrafish to F–53B at four …

The eye is a complex sensory organ that enables visual perception of the world. The
dysfunction of any of these tissues can impair vision. Conduction studies on laboratory …

The presence of contaminants in the environment has increased in recent years, and studies
have demonstrated that these contaminants have the ability to penetrate the blood–retinal …

Mutations in USH2A are the most frequent cause of Usher syndrome and autosomal
recessive nonsyndromic retinitis pigmentosa. To unravel the pathogenic mechanisms …

Our ears are remarkable sensory organs, providing the important senses of balance and
hearing. The complex structure of the inner ear, or 'labyrinth', along with the assorted …

RNA-binding proteins control the metabolism of RNAs at all stages of their lifetime. They are
critically required for the post-transcriptional regulation of gene expression in a wide variety …

Visual impairment and blindness are common and seriously affect people's work and quality
of life in the world. Therefore, the effective therapies for eye diseases are of high priority …