Immunotherapy with checkpoint inhibitors is well established as an effective treatment for
non-small cell lung cancer and melanoma. The list of approved indications for treatment with …

Lung cancer accounts for the main proportion of malignancy-related deaths and most
patients are diagnosed at an advanced stage. Immunotherapy and targeted therapy have …

Immunotherapy has become a fourth pillar in the treatment of brain tumors and, when
combined with radiation therapy, may improve patient outcomes and reduce the …

Background Programmed cell death ligand-1 (PD-L1) is an antitumor immunity molecule
and a great target to cure oral cancer; nonetheless, the limited success can be attributed to …

Simple Summary The immune response has been shown to be a promising indicator to
predict the clinical behavior of many cancers, including head and neck cancer. Tumor …

Eukaryotic initiation factor 5A2 (eIF5A2) is overexpressed in many types of cancer, and
spermidine-mediated eIF5A hypusination (eIF5Ahpu) appears to be essential to most of …

Background: N6-methyladenosine (m6A), 5-methylcytosine (m5C) and N1-methyladenosine
(m1A) are the main RNA methylation modifications involved in the progression of cancer …

Head and neck squamous cell carcinoma (HNSCC) encompass a group of complex entities
of tumours affecting the aerodigestive upper tract. The main risk factors are strongly related …

Head and neck cancer is affecting a large sort of population. Many treatments are available
on a regular base, but they have their limitations. Diagnosis in the early stage is essential to …

Background The prognostic significance of tumour budding (TB) and minimal cell nest size
(MCNS) was shown in human papillomavirus (HPV)-negative head and neck squamous cell …