Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société …
R Guilhaumou, S Benaboud, Y Bennis… - Critical Care, 2019 - Springer
Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …
Optimizing antimicrobial use: challenges, advances and opportunities
An optimal antimicrobial dose provides enough drug to achieve a clinical response while
minimizing toxicity and development of drug resistance. There can be considerable …
minimizing toxicity and development of drug resistance. There can be considerable …
Current and future perspectives in the treatment of multidrug-resistant Gram-negative infections
M Bassetti, J Garau - Journal of Antimicrobial Chemotherapy, 2021 - academic.oup.com
Microbial resistance is a serious threat to human health worldwide. Among the World Health
Organisation's list of priority resistant bacteria, three are listed as critical—the highest level of …
Organisation's list of priority resistant bacteria, three are listed as critical—the highest level of …
Antibiotic therapeutic drug monitoring in intensive care patients treated with different modalities of extracorporeal membrane oxygenation (ECMO) and renal …
D Kühn, C Metz, F Seiler, H Wehrfritz, S Roth… - Critical Care, 2020 - Springer
Background Effective antimicrobial treatment is key to reduce mortality associated with
bacterial sepsis in patients on intensive care units (ICUs). Dose adjustments are often …
bacterial sepsis in patients on intensive care units (ICUs). Dose adjustments are often …
Therapeutic drug monitoring-guided continuous infusion of piperacillin/tazobactam significantly improves pharmacokinetic target attainment in critically ill patients: a …
DC Richter, O Frey, A Röhr, JA Roberts, A Köberer… - Infection, 2019 - Springer
Purpose Standard dosing and intermittent bolus application (IB) are important risk factors for
pharmacokinetic (PK) target non-attainment during empirical treatment with β-lactams in …
pharmacokinetic (PK) target non-attainment during empirical treatment with β-lactams in …
The ONTAI study–a survey on antimicrobial dosing and the practice of therapeutic drug monitoring in German intensive care units
U Liebchen, M Paal, C Scharf, I Schroeder… - Journal of critical …, 2020 - Elsevier
Purpose Optimization of antibiotic therapy is still urgently needed in critically ill patients. The
aim of the ONTAI survey (online survey on the use of Therapeutic Drug Monitoring of …
aim of the ONTAI survey (online survey on the use of Therapeutic Drug Monitoring of …
The higher the better? Defining the optimal beta-lactam target for critically ill patients to reach infection resolution and improve outcome
C Scharf, U Liebchen, M Paal, M Taubert… - Journal of Intensive …, 2020 - Springer
Objectives Beta-lactam antibiotics are often subject to therapeutic drug monitoring, but
breakpoints of target attainment are mostly based on expert opinions. Studies that show a …
breakpoints of target attainment are mostly based on expert opinions. Studies that show a …
Therapeutic drug monitoring of meropenem and piperacillin in critical illness—experience and recommendations from one year in routine clinical practice
C Scharf, M Paal, I Schroeder, M Vogeser, R Draenert… - Antibiotics, 2020 - mdpi.com
Various studies have reported insufficient beta-lactam concentrations in critically ill patients.
The extent to which therapeutic drug monitoring (TDM) in clinical practice can reduce …
The extent to which therapeutic drug monitoring (TDM) in clinical practice can reduce …
Personalized application of antimicrobial drugs in pediatric patients with augmented renal clearance: a review of literature
WX Xu, Q Qu, XQ Teng, HH Zhuang, SF Liu… - European Journal of …, 2024 - Springer
The effect of renal functional status on drug metabolism is a crucial consideration for
clinicians when determining the appropriate dosage of medications to administer. In critically …
clinicians when determining the appropriate dosage of medications to administer. In critically …
Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on …
S Greppmair, A Brinkmann, A Roehr, O Frey… - Intensive Care …, 2023 - Springer
Purpose Inadequate piperacillin (PIP) exposure in intensive care unit (ICU) patients
threatens therapeutic success. Model-informed precision dosing (MIPD) might be promising …
threatens therapeutic success. Model-informed precision dosing (MIPD) might be promising …