[HTML][HTML] Preclinical evaluation of manufacturable SARS-CoV-2 spike virus-like particles produced in Chinese Hamster Ovary cells

SP Alpuche-Lazcano, M Stuible, B Akache… - Communications …, 2023 - nature.com
Background As the COVID-19 pandemic continues to evolve, novel vaccines need to be
developed that are readily manufacturable and provide clinical efficacy against emerging …

Intranasal administration of unadjuvanted SARS‐CoV‐2 spike antigen boosts antigen‐specific immune responses induced by parenteral protein subunit vaccine …

G Agbayani, B Akache, TM Renner… - European Journal of …, 2024 - Wiley Online Library
With the continued transmission of SARS‐CoV‐2 across widely vaccinated populations, it
remains important to develop new vaccines and vaccination strategies capable of providing …

[HTML][HTML] Archaeal ether lipids improve internalization and transfection with mRNA lipid nanoparticles

VL Sedlmayr, S Schobesberger, S Spitz, P Ertl… - European Journal of …, 2024 - Elsevier
Neutral and positively charged archaeal ether lipids (AEL) have been studied for their
utilization as novel delivery systems for pDNA, showing efficient immune response with a …

[HTML][HTML] In Silico Prophage Analysis of Halobacterium salinarum ATCC 33170

DL Peters, B Akache, W Chen, MJ McCluskie - Applied Microbiology, 2024 - mdpi.com
The extremophile Halobacterium salinarum is an aerobic archaeon that has adapted to
thrive in high-salt environments such as salted fish, hypersaline lakes, and salterns …

[HTML][HTML] A Broad-Spectrum Multi-Antigen mRNA/LNP-Based Pan-Coronavirus Vaccine Induced Potent Cross-Protective Immunity Against Infection and Disease …

S Prakash, NR Dhanushkodi, M Singer, A Quadiri… - bioRxiv, 2024 - ncbi.nlm.nih.gov
The first-generation Spike-alone-based COVID-19 vaccines have successfully contributed to
reducing the risk of hospitalization, serious illness, and death caused by SARS-CoV-2 …

Archaeal Lipid Vesicles as Immune Modulators, Adjuvants and Vaccine Carriers: A Review of the Past and Current Trends.

FN Esfahani, SM Naghib, O Atrooz, S Ataei, G Ak… - 2024 - preprints.org
Lipidic carriers employed for the entrapment, encapsulation and precise targeting the
bioactive compounds offer significant advantages to the biomedical, pharmaceutical …