PURPOSE: The mucosa of the small intestine encompasses about 90% of the luminal
surface area of the digestive system, but only 2% of the total annual gastrointestinal cancer …

Background Inflammatory bowel diseases (IBD) result from an interaction between genetic
and environmental factors. Preliminary findings suggest that susceptibility genes differ …

Inflammatory bowel disease (IBD) typically manifests as either ulcerative colitis (UC) or
Crohn's disease (CD). Systematic identification of susceptibility genes for IBD has thus far …

Background Differential immunoregulatory capabilities of probiotic Lactobacillus were
explored in the context of pediatric Crohn's disease. Experimental strategies addressed …

Monoclonal antibodies (mAbs) are currently the largest and most dominant class of
therapeutic proteins. Inter-individual variability has been observed for several mAbs; …

The gastrointestinal tract is lined by a single layer of epithelial cells that secrete mucus
toward the lumen, which collectively separates the immune sentinels in the underlying …

Objective: To evaluate the relationship between biomarker levels and disease activity and
the spinal inflammation detected by magnetic resonance imaging (MRI) in patients with …

Mycobacterium paratuberculosis has been suggested to be involved in the pathogenesis of
Crohn's disease (CD). The importance of microorganisms in CD is supported by the …

AIM: To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in
genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9, tissue inhibitors of …

The breakdown of gastrointestinal tract immune homeostasis leads to Crohn's disease (CD).
Mesenchymal stem cells (MSCs) have demonstrated clinical efficacy in treating CD in …