CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond

AF Russo, DL Hay - Physiological reviews, 2023 - journals.physiology.org
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

[HTML][HTML] Migraine and neuroinflammation: the inflammasome perspective

O Kursun, M Yemisci… - The Journal of …, 2021 - Springer
Background Neuroinflammation has an important role in the pathophysiology of migraine,
which is a complex neuro-glio-vascular disorder. The main aim of this review is to highlight …

The pathophysiology of migraine: implications for clinical management

A Charles - The Lancet Neurology, 2018 - thelancet.com
The understanding of migraine pathophysiology is advancing rapidly. Improved
characterisation and diagnosis of its clinical features have led to the view of migraine as a …

Sex differences in the epidemiology, clinical features, and pathophysiology of migraine

KG Vetvik, EA MacGregor - The Lancet Neurology, 2017 - thelancet.com
Migraine is two to three times more prevalent in women than men, and women report a
longer attack duration, increased risk of headache recurrence, greater disability, and a …

Delayed cerebral ischemia after subarachnoid hemorrhage: beyond vasospasm and towards a multifactorial pathophysiology

JR Geraghty, FD Testai - Current atherosclerosis reports, 2017 - Springer
Abstract Purpose of Review Delayed cerebral ischemia (DCI) is common after subarachnoid
hemorrhage (SAH) and represents a significant cause of poor functional outcome. DCI was …

Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: review and recommendations of the COSBID research group

JP Dreier, M Fabricius, C Ayata… - Journal of Cerebral …, 2017 - journals.sagepub.com
Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal
transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable …

Calcitonin gene-related peptide (CGRP): a new target for migraine

AF Russo - Annual review of pharmacology and toxicology, 2015 - annualreviews.org
Migraine is a neurological disorder that manifests as a debilitating headache associated
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …

Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations

D Pietrobon, MA Moskowitz - Nature Reviews Neuroscience, 2014 - nature.com
Punctuated episodes of spreading depolarizations erupt in the brain, encumbering tissue
structure and function, and raising fascinating unanswered questions concerning their …

[HTML][HTML] The stroke-migraine depolarization continuum

JP Dreier, C Reiffurth - Neuron, 2015 - cell.com
The term spreading depolarization (SD) refers to waves of abrupt, sustained mass
depolarization in gray matter of the CNS. SD, which spreads from neuron to neuron in …

[图书][B] Electrical impedance tomography: methods, history and applications

A Adler, D Holder - 2021 - books.google.com
With contributions from leading international researchers, this second edition of Electrical
Impedance Tomography: Methods, History and Applications has been fully updated …