Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome
drives release of the proinflammatory cytokines interleukin (IL)-1 β and IL-18 and induces …

Excessive activation of microglia and subsequent release of proinflammatory cytokines play
a crucial role in neuroinflammation and neurodegeneration in Parkinson's disease (PD) …

NLRP3 inflammasome is a vital player in macrophages pyroptosis, which is a type of
proinflammatory cell-death and takes part in the pathogenesis of atherosclerosis. In this …

Wilson's disease (WD) is an inherited disorder characterized by excessive accumulation of
copper in the body, particularly in the liver and brain. In the central nervous system (CNS) …

Intracerebral hemorrhage (ICH) is the most fatal subtype of stroke; there is still a lack of
effective treatment. Microglia are a major component of the innate immune system, and they …

Only a few types of inflammasomes have been described in central nervous system cells.
Among these, the absent in melanoma 2 (AIM2) inflammasome is primarily found in …

Evidence suggests that various innate immune system components are involved in
pathological inflammatory conditions. Among these components, the NLR family pyrin …

Podocyte damage mediated by in situ complement activation in the glomeruli is a key factor
in the pathogenesis of membranous nephropathy (MN), but the molecular mechanism has …

Early brain injury is a series of pathophysiological changes and direct damage of brain
tissue within 72 hours after subarachnoid hemorrhage before cerebral vasospasm occurs …

Stroke is one of the leading causes of mortality and morbidity worldwide. The bloodbrain
barrier (BBB) is a characteristic structure of microvessel within the brain. Under normal …