The nucleophosmin (NPM1) gene encodes for a multifunctional chaperone protein that is
localized in the nucleolus but continuously shuttles between the nucleus and cytoplasm …

Simple Summary The nucleophosmin 1 (NPM1) gene is mutated in approximately one-third
of newly diagnosed acute myeloid leukemia (AML) cases. NPM1mutated AML (NPM1 mut …

Objectives: Identify the epidemiology of acute myeloid leukemia. Describe the physical exam
of a patient with acute myeloid leukemia, Review the management of acute myeloid …

Monotherapy with Menin inhibitor (MI), eg, SNDX-5613, induces clinical remissions in
patients with relapsed/refractory AML harboring MLL1-r or mtNPM1, but most patients either …

The most common kind of acute leukemia in adults is acute myeloid leukemia (AML), which
is often treated with induction chemotherapy regimens followed by consolidation or …

Simple Summary Next–Generation Sequencing (NGS) has provided a deeper genetic
understanding of acute myeloid leukemia (AML) that has been recently incorporated into …

Mutations in NPM1, also known as nucleophosmin-1, B23, NO38, or numatrin, are seen in
approximately one-third of patients with acute myeloid leukaemia (AML). A plethora of …

The direct targeting of chromatin-associated proteins is increasingly recognized as a
potential therapeutic strategy for the treatment of cancer. In this review, we discuss a …

Acute myeloid leukaemias harbouring a rearrangement of the mixed lineage leukaemia
gene (MLL) are aggressive haematopoietic malignancies that relapse early and have a poor …

Acute myeloid leukemia (AML) is a deadly disease and the most common leukemia in adult
with clonal heterogeneity and abnormity in myeloid lineages, which has been recognized …