A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant
The airways and alveoli of the human respiratory tract are lined by two distinct types of
epithelium, which are the primary targets of respiratory viruses. We previously established …
epithelium, which are the primary targets of respiratory viruses. We previously established …
[HTML][HTML] SARS-CoV-2 infection of airway epithelial cells
G Ryu, HW Shin - Immune network, 2021 - ncbi.nlm.nih.gov
Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has been spreading worldwide since its outbreak in December 2019, and …
(SARS-CoV-2) has been spreading worldwide since its outbreak in December 2019, and …
Human organoids and organs‐on‐chips for addressing COVID‐19 challenges
Abstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), poses an imminent threat to our lives. Although …
syndrome coronavirus 2 (SARS‐CoV‐2), poses an imminent threat to our lives. Although …
Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2 …
pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2 …
An integrated radiologic-pathologic understanding of COVID-19 pneumonia
This article reviews the radiologic and pathologic findings of the epithelial and endothelial
injuries in COVID-19 pneumonia to help radiologists understand the fundamental nature of …
injuries in COVID-19 pneumonia to help radiologists understand the fundamental nature of …
A distal lung organoid model to study interstitial lung disease, viral infection and human lung development
I Matkovic Leko, RT Schneider, TA Thimraj… - Nature …, 2023 - nature.com
Organoids have been an exciting advancement in stem cell research. Here we describe a
strategy for directed differentiation of human pluripotent stem cells into distal lung organoids …
strategy for directed differentiation of human pluripotent stem cells into distal lung organoids …
[HTML][HTML] An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection
It is urgent to develop disease models to dissect mechanisms regulating severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we derive airway …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we derive airway …
Organoid-based expansion of patient-derived primary alveolar type 2 cells for establishment of alveolus epithelial Lung-Chip cultures
S van Riet, A van Schadewijk… - … of Physiology-Lung …, 2022 - journals.physiology.org
Abstract Development of effective treatment strategies for lung tissue destruction as seen in
emphysema would greatly benefit from representative human in vitro models of the alveolar …
emphysema would greatly benefit from representative human in vitro models of the alveolar …
Mechanisms of lung injury induced by SARS-CoV-2 infection
The lung is the major target organ of SARS-CoV-2 infection, which causes COVID-19. Here,
we outline the multistep mechanisms of lung epithelial and endothelial injury induced by …
we outline the multistep mechanisms of lung epithelial and endothelial injury induced by …
[HTML][HTML] Alveolar type II cells and pulmonary surfactant in COVID-19 era
A Calkovska, M Kolomaznik, V Calkovsky - Physiological research, 2021 - ncbi.nlm.nih.gov
In this review, we discuss the role of pulmonary surfactant in the host defense against
respiratory pathogens, including novel coronavirus SARS-CoV-2. In the lower respiratory …
respiratory pathogens, including novel coronavirus SARS-CoV-2. In the lower respiratory …