Organoids are tiny, self-organized, three-dimensional tissue cultures that are derived from
the differentiation of stem cells. The growing interest in the use of organoids arises from their …

In late 2021, the highly mutated SARS-CoV-2 Omicron variant emerged, raising concerns
about its potential extensive immune evasion, increased transmissibility and pathogenicity …

Respiratory infections remain a major global health concern. Tuberculosis is one of the top
10 causes of death worldwide, while infections with Non‐Tuberculous Mycobacteria are …

Viruses are submicroscopic, obligate intracellular parasites that carry either DNA or RNA as
their genome, protected by a capsid. Viruses are genetic entities that propagate by using the …

The COVID-19 pandemic has emphasised the need to develop effective treatments to
combat emerging viruses. Model systems that poorly represent a virus' cellular environment …

Organoids are complex multicellular three-dimensional (3D) in vitro models that are
designed to allow accurate studies of the molecular processes and pathologies of human …

Background In the aftermath of Covid-19, some patients develop a fibrotic lung disease, ie,
post-COVID-19 lung disease (PCLD), for which we currently lack insights into pathogenesis …

The coronavirus disease 2019 (COVID-19) pandemic has caused considerable socio-
economic burden, which fueled the development of treatment strategies and vaccines at an …

The surfaces of human internal organs are lined by a mucus layer that ensures symbiotic
relationships with commensal microbiome while protecting against potentially injurious …

There is an unmet need for preclinical models to understand the pathogenesis of human
respiratory viruses and predict responsiveness to immunotherapies. Airway organoids can …