3D lung tissue models for studies on SARS-CoV-2 pathophysiology and therapeutics
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing the coronavirus
disease 2019 (COVID-19), has provoked more than six million deaths worldwide and …
disease 2019 (COVID-19), has provoked more than six million deaths worldwide and …
SARS-CoV-2 ORF8 accessory protein is a virulence factor
M Bello-Perez, J Hurtado-Tamayo, AZ Mykytyn… - Mbio, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes six accessory
proteins (3a, 6, 7a, 7b, 8, and 9b) for which limited information is available on their role in …
proteins (3a, 6, 7a, 7b, 8, and 9b) for which limited information is available on their role in …
Two different therapeutic approaches for SARS-CoV-2 in hiPSCs-derived lung organoids
P Spitalieri, F Centofanti, M Murdocca, MG Scioli… - Cells, 2022 - mdpi.com
The global health emergency for SARS-CoV-2 (COVID-19) created an urgent need to
develop new treatments and therapeutic drugs. In this study, we tested, for the first time on …
develop new treatments and therapeutic drugs. In this study, we tested, for the first time on …
Comparative Pathogenesis of Severe Acute Respiratory Syndrome Coronaviruses
Over the last two decades the world has witnessed the global spread of two genetically
related highly pathogenic coronaviruses, severe acute respiratory syndrome coronavirus …
related highly pathogenic coronaviruses, severe acute respiratory syndrome coronavirus …
Human Lung Organoids—A Novel Experimental and Precision Medicine Approach
L Kühl, P Graichen, N von Daacke, A Mende… - Cells, 2023 - mdpi.com
The global burden of respiratory diseases is very high and still on the rise, prompting the
need for accurate models for basic and translational research. Several model systems are …
need for accurate models for basic and translational research. Several model systems are …
Advanced in vitro lung models for drug and toxicity screening: the promising role of induced pluripotent stem cells
The substantial socioeconomic burden of lung diseases, recently highlighted by the
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …
Cathepsins and SARS‐CoV‐2 infection: From pathogenic factors to potential therapeutic targets
S Zhao, M Jiang, H Qing, J Ni - British Journal of Pharmacology, 2023 - Wiley Online Library
Abstract Coronavirus disease‐19 (COVID‐19) is caused by severe acute respiratory
syndrome‐coronavirus‐2 (SARS‐CoV‐2) infection. The COVID‐19 pandemic began in …
syndrome‐coronavirus‐2 (SARS‐CoV‐2) infection. The COVID‐19 pandemic began in …
Engineering in vitro immune-competent tissue models for testing and evaluation of therapeutics
JH Hammel, JM Zatorski, SR Cook… - Advanced drug delivery …, 2022 - Elsevier
Advances in 3D cell culture, microscale fluidic control, and cellular analysis have enabled
the development of more physiologically-relevant engineered models of human organs with …
the development of more physiologically-relevant engineered models of human organs with …
Organoid technology and applications in lung diseases: Models, mechanism research and therapy opportunities
J Chen, F Na - Frontiers in Bioengineering and Biotechnology, 2022 - frontiersin.org
The prevalency of lung disease has increased worldwide, especially in the aging
population. It is essential to develop novel disease models, that are superior to traditional …
population. It is essential to develop novel disease models, that are superior to traditional …
[HTML][HTML] Polyhexamethylene guanidine phosphate increases stress granule formation in human 3D lung organoids under respiratory syncytial virus infection
Polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, is known to
cause lung toxicity, including inflammation and pulmonary fibrosis. In this study, we aimed to …
cause lung toxicity, including inflammation and pulmonary fibrosis. In this study, we aimed to …