[HTML][HTML] SARS-CoV-2 Omicron variant is attenuated for replication in a polarized human lung epithelial cell model
C Mache, J Schulze, G Holland, D Bourquain… - Communications …, 2022 - nature.com
SARS-CoV-2 and its emerging variants of concern remain a major threat for global health.
Here we introduce an infection model based upon polarized human Alveolar Epithelial …
Here we introduce an infection model based upon polarized human Alveolar Epithelial …
[HTML][HTML] Novel opportunities from bioimaging to understand the trafficking and maturation of intracellular pulmonary surfactant and its role in lung diseases
Pulmonary surfactant (PS), a complex mixture of lipids and proteins, is essential for
maintaining proper lung function. It reduces surface tension in the alveoli, preventing …
maintaining proper lung function. It reduces surface tension in the alveoli, preventing …
[HTML][HTML] Organotypic human lung bud microarrays identify BMP-dependent SARS-CoV-2 infection in lung cells
Although lung disease is the primary clinical outcome in COVID-19 patients, how SARS-CoV-
2 induces lung pathology remains elusive. Here we describe a high-throughput platform to …
2 induces lung pathology remains elusive. Here we describe a high-throughput platform to …
Human metapneumovirus infection of organoid-derived human bronchial epithelium represents cell tropism and cytopathology as observed in in vivo models
P Ribó-Molina, S van Nieuwkoop, AZ Mykytyn… - Msphere, 2024 - Am Soc Microbiol
Human metapneumovirus (HMPV), a member of the Pneumoviridae family, causes upper
and lower respiratory tract infections in humans. In vitro studies with HMPV have mostly …
and lower respiratory tract infections in humans. In vitro studies with HMPV have mostly …
[HTML][HTML] Zinc supplementation augments the suppressive effects of repurposed NF-κB inhibitors on ACE2 expression in human lung cell lines
MC Lee, YK Chen, JJ Tsai-Wu, YJ Hsu, BR Lin - Life Sciences, 2021 - Elsevier
Aims Angiotensin-converting enzyme 2 (ACE2) is a key negative regulator of the renin-
angiotensin system and also a major receptor for severe acute respiratory syndrome …
angiotensin system and also a major receptor for severe acute respiratory syndrome …
SNHG15 aids SARS-CoV-2 entry via RABL2A
ABSTRACT Angiotensin-converting enzyme 2 (ACE2) and several proteins have been
identified as entry factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
identified as entry factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
In vitro high-content tissue models to address precision medicine challenges
The field of precision medicine allows for tailor-made treatments specific to a patient and
thereby improve the efficiency and accuracy of disease prevention, diagnosis, and treatment …
thereby improve the efficiency and accuracy of disease prevention, diagnosis, and treatment …
[HTML][HTML] Alveolar Organoids in Lung Disease Modeling
E Purev, K Bahmed, B Kosmider - Biomolecules, 2024 - mdpi.com
Lung organoids display a tissue-specific functional phenomenon and mimic the features of
the original organ. They can reflect the properties of the cells, such as morphology, polarity …
the original organ. They can reflect the properties of the cells, such as morphology, polarity …
[HTML][HTML] Three-dimensional cell culture methods in infectious diseases and vaccine research
G Varan, S Unal - Future Pharmacology, 2023 - mdpi.com
Cells, the basic structures of all living organisms, reside in an extracellular matrix consisting
of a complex three-dimensional architecture and interact with neighboring cells both …
of a complex three-dimensional architecture and interact with neighboring cells both …
[HTML][HTML] Organoid modeling of lung-resident immune responses to SARS-CoV-2 infection
Tissue-resident immunity underlies essential host defenses against pathogens, but analysis
in humans has lacked in vitro model systems where epithelial infection and accompanying …
in humans has lacked in vitro model systems where epithelial infection and accompanying …