Entomopathogenic fungi (EPF) distribute in different fungal phyla with variable host ranges
and play essential role in regulating insect populations by infecting hosts via cuticle …

Highlights•Insect cuticles are inhabited by diverse microorganisms.•Insect ectomicrobiomes
can mediate colonization resistance against fungal parasites.•Fungal pathogens can …

In addition to innate immunity in a physiological context, insects have evolved behavioral
defenses against parasite attacks. Here, we report that Drosophila can sense the CFEM …

Insects can assemble defensive microbiomes on their body surfaces to defend against
fungal parasitic infections. The strategies employed by fungal pathogens to combat host …

Diverse β-carboline (βC) alkaloids are produced by microbes, plants, and animals with
myriad bioactivities and drug potentials. However, the biosynthetic mechanism of βCs …

Insects constitute approximately 75% of the world's recognized fauna, with the majority of
species considered as pests. Entomopathogenic fungi (EPF) are parasitic microorganisms …

Fungal secondary metabolites with antibiotic activities can promote fungal adaptation to
diverse environments. Besides the global regulator, individual biosynthetic gene clusters …

The nortriterpenoid helvolic acid (HA) has potent antibiotic activities and can be produced by
different fungi, yet HA function remains elusive. Here, we report the chemical biology of HA …

The in-depth study of fungal secondary metabolites (SMs) over the past few years has led to
the discovery of a vast number of novel fungal SMs, some of which possess good biological …

Entomopathogenic fungi (EPF) infect insects by landing on and penetrating cuticles.
Emerging evidence has shown that, prior to the invasion of insects, fungal cells have to …