Pain is common in cancer patients, particularly in the advanced stage of disease when the
prevalence is estimated to be more than 70%[1], contributing to poor physical and emotional …

Opioids produce strong analgesia but their use is limited by a paradoxical hypersensitivity
named opioid-induced hyperalgesia (OIH) that may be associated to analgesic tolerance. In …

Clinical studies comparing the response and side effects of various opioids have not been
able to show robust differences between drugs. Hence, recommendations of the regulatory …

Background: Opioid use in patients with renal impairment can lead to increased adverse
effects. Opioids differ in their effect in renal impairment in both efficacy and tolerability. This …

Purpose To review the recent literature on opioid rotation (ie, switching from one opioid drug
to another or changing an opioid's administration route) in cancer patients experiencing …

In this paper we describe the results of a systematic search of the literature on conversion
ratios during opioid switching. This is part of a project of the European Palliative Care …

Methadone is increasingly being used for its analgesic properties. Despite the increasing
popularity, many healthcare providers are not familiar with methadone's complex …

Opioids affect motor and sensory function throughout the gastrointestinal tract, and are
frequently associated with a number of gastrointestinal symptoms including constipation …

Abstract Editor's Perspective What We Already Know about This Topic The intraoperative
administration of methadone is effective in reducing postoperative pain Preventative …

Background: The intensity of pain after cardiac surgery is often underestimated, and
inadequate pain control may be associated with poorer quality of recovery. The aim of this …