The link between neuroinflammation and the neurovascular unit in synucleinopathies

Q Wang, J Zheng, S Pettersson, R Reynolds… - Science advances, 2023 - science.org
The neurovascular unit (NVU) is composed of vascular cells, glial cells, and neurons. As a
fundamental functional module in the central nervous system, the NVU maintains …

[HTML][HTML] Efficacy of repetitive transcranial magnetic stimulation in Parkinson's disease: a systematic review and meta-analysis of randomised controlled trials

W Zhang, B Deng, F Xie, H Zhou, JF Guo, H Jiang… - …, 2022 - thelancet.com
Background Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive form of
brain stimulation that positively regulates the motor and non-motor symptoms of Parkinson's …

Inflammasomes in neurological disorders—mechanisms and therapeutic potential

KA Ravichandran, MT Heneka - Nature Reviews Neurology, 2024 - nature.com
Inflammasomes are molecular scaffolds that are activated by damage-associated and
pathogen-associated molecular patterns and form a key element of innate immune …

Breakthroughs in nanozyme-inspired application diversity

Q Zhang, L Song, K Zhang - Materials Chemistry Frontiers, 2023 - pubs.rsc.org
The rapid advancement of nanomaterials has promoted the booming of nanozymes capable
of mimicking natural enzymes. As ideal alternatives to natural enzymes, nanozymes are …

[HTML][HTML] Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease

HY Yu, T Sun, Z Wang, H Li, D Xu, J An… - Neural Regeneration …, 2023 - journals.lww.com
Use of glucagon-like peptide-1 receptor agonist or dipeptidyl peptidase 4 inhibitor has been
shown to lower the incidence of Parkinson's disease in patients with diabetes mellitus …

[HTML][HTML] The role of tyrosine hydroxylase–dopamine pathway in Parkinson's disease pathogenesis

ZD Zhou, WT Saw, PGH Ho, ZW Zhang, L Zeng… - Cellular and Molecular …, 2022 - Springer
Background Parkinson's disease (PD) is characterized by selective and progressive
dopamine (DA) neuron loss in the substantia nigra and other brain regions, with the …

[HTML][HTML] Role of NLRP3 inflammasome in Parkinson's disease and therapeutic considerations

LTN Nguyen, HD Nguyen, YJ Kim… - Journal of …, 2022 - content.iospress.com
Parkinson's disease (PD) is the second most common neurodegenerative disease, with two
main pathological features: misfolded α-synuclein protein accumulation and …

Dl-3-n-butylphthalide activates Nrf2, inhibits ferritinophagy, and protects MES23. 5 dopaminergic neurons from ferroptosis

Z Ye, C Li, S Liu, H Liang, J Feng, D Lin, Y Chen… - Chemico-biological …, 2023 - Elsevier
Ferroptosis, a newly identified iron-dependent form of cell death, has recently been
implicated in the pathogenesis of Parkinson's disease (PD). Dl-3-n-butylphthalide (NBP) …

[HTML][HTML] Alzheimer's disease and neuroinflammation: will new drugs in clinical trials pave the way to a multi-target therapy?

D Melchiorri, S Merlo, B Micallef, JJ Borg… - Frontiers in …, 2023 - frontiersin.org
Despite extensive research, no disease-modifying therapeutic option, able to prevent, cure
or halt the progression of Alzheimer's disease [AD], is currently available. AD, a devastating …

[HTML][HTML] Role of Exosomes in the Pathogenesis and Theranostic of Alzheimer's Disease and Parkinson's Disease

A He, M Wang, X Li, H Chen, K Lim, L Lu… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common
neurodegenerative diseases (NDDs) threatening the lives of millions of people worldwide …