Acute lymphoblastic leukemia (ALL) is a neoplastic disease characterized by clonal
expansion of leukemic cells in the bone marrow (BM), lymph nodes, thymus, or spleen. ALL …

The last 4 decades have seen major advances in understanding the genetic basis of acute
myeloid leukemia (AML), paralleled by substantial improvements in survival of children and …

Purpose To analyze the frequency and associations with prognostic markers and outcome of
mutations in IDH genes encoding isocitrate dehydrogenases in adult de novo …

Purpose To evaluate the prognostic significance of the international European LeukemiaNet
(ELN) guidelines for reporting genetic alterations in acute myeloid leukemia (AML). Patients …

Abstract Recently, the European LeukemiaNet (ELN) revised its genetic-risk classification of
acute myeloid leukemia (AML). We categorized 1637 adults with AML treated with …

Purpose To determine the association of RUNX1 mutations with therapeutic outcome in
younger and older patients with primary cytogenetically normal acute myeloid leukemia (CN …

Purpose To determine the frequency of TET2 mutations, their associations with clinical and
molecular characteristics and outcome, and the associated gene-and microRNA-expression …

The associations of mutations in the enhancer of trithorax and polycomb family gene ASXL1
with pretreatment patient characteristics, outcomes, and gene-/microRNA-expression …

Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides, located within
the intergenic stretches or overlapping antisense transcripts of protein coding genes …

Purpose To determine the frequency of DNMT3A mutations, their associations with clinical
and molecular characteristics and outcome, and the associated gene-and microRNA …